Titre du document / Document title

Treatment of periodontitis by local administration of minocycline microspheres : A controlled trial

Auteur(s) / Author(s)

WILLIAMS Ray C. ; PAQUETTE David W. ; OFFENBACHER Steven ; ADAMS Donald F. ; ARMITAGE Gary C. ; BRAY Kim ; CATON Jack ; COCHRAN David L. ; DRISKO Connie H. ; FIORELLINI Joseph P. ; GIANNOBILE William V. ; GROSSI Sara ; GUERRERO Denise M. ; JOHNSON Georgia K. ; LAMSTER Ira B. ; MAGNUSSON Ingvar ; ORINGER Richard J. ; PERSSON G. Rutger ; VAN DYKE Thomas E. ; WOLFF Larry F. ; SANTUCCI Edward A. ; RODDA Bruce E. ; LESSEM Jan ;

Résumé / Abstract

Background: Periodontitis is an inflammatory condition of tooth-supporting tissues that is usually treated by mechanical removal of plaque and microorganisms that adhere to teeth. This treatment, known as scaling and rootplaning, is not optimally effective. Adjunctive therapy with locally delivered antimicrobials has resulted in improved clinical outcomes such as probing depth reduction. This article reports on the efficacy and safety of locally administered microencapsulated minocycline. Methods: Seven hundred forty-eight (748) patients with moderate to advanced periodontitis were enrolled in a multi-center trial and randomized to 1 of 3 treatment arms: 1) scaling and root planing (SRP) alone; 2) SRP plus vehicle; or 3) SRP plus minocycline microspheres. The primary outcome measure was probing depth reduction at 9 months. Clinical assessments were performed at baseline and 1, 3, 6, and 9 months. Results: Minocycline microspheres plus scaling and root planing provided substantially more probing depth reduction than either SRP alone or SRP plus vehicle. The difference reached statistical significance after the first month and was maintained throughout the trial. The improved outcome was observed to be independent of patients' smoking status, age, gender, or baseline disease level. There was no difference in the incidence of adverse effects among treatment groups. Conclusions: Scaling and root planing plus minocycline microspheres is more effective than scaling and root planing alone in reducing probing depths in periodontitis patients.

Revue / Journal Title

Journal of periodontology   ISSN 0022-3492 

Source / Source

2001, vol. 72, n^o11, pp. 1535-1544 [10 page(s) (article)]

Langue / Language

Anglais

Editeur / Publisher

American Academy of Periodontology, Chicago, IL, ETATS-UNIS  (1970) (Revue)

Localisation / Location

INIST-CNRS, Cote INIST : 874, 35400010024918.0100