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Titre du document / Document title

Role of nitric oxide in experimental models of psychosis in rats

Auteur(s) / Author(s)

GUPTA M. (1) ; BALAKRISHNAN S. (1) ; PANDHI P. (1) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Department of Pharmacology, Postgraduate Institute of Medical Education & Research, Chandigarh, INDE

Résumé / Abstract

The aim of our study was to investigate the effects of the NO precursor L-arginine and the nitric oxide synthase inhibitor Nω-nitro-L-arginine (L-NORAG) on amphetamine-induced stereotypy, haloperidol-induced catalepsy and conditioned avoidance response (CAR) in rats. Amphetamine (3 mg/kg i.p.) was used for the induction of stereotypy, while for the induction of catalepsy and CAR, haloperidol (2 mg/kg i.p.) was used. This study was divided into 2 parts-acute administration of L-arginine (150 mg/kg i.p.) and L-NOARG (50 mg/kg i.p.) and chronic administration of L-arginine (150 mg/kg/day i.p.) and L-NOARG (50 mg/kg/day i.p.) for 5 days. We found that L-arginine inhibited amphetamine-induced stereotypy and haloperidolinduced catalepsy, but intensified CAR. On the other hand, L-NOARG intensified stereotypy and catalepsy but inhibited CAR. Also, there was no significant difference between the scores of acute and chronic administration of L-arginine and L-NOARG. It is concluded from our study that nitric oxide produces conflicting results on various models of psychosis. L-arginine might be useful as an antipsychotic without causing extrapyramidal symptoms.

Revue / Journal Title

Methods and findings in experimental and clinical pharmacology    ISSN  0379-0355 

Source / Source

2001, vol. 23, no9, pp. 497-500 (16 ref.)

Langue / Language

Anglais

Editeur / Publisher

Prous, Barcelona, ESPAGNE  (1979) (Revue)

Mots-clés anglais / English Keywords

Enzyme

;

Oxidoreductases

;

Vertebrata

;

Mammalia

;

Rodentia

;

Aminoacid

;

Neuroleptic

;

Psychotropic

;

Treatment

;

Chemotherapy

;

Nitric-oxide synthase

;

Enzyme inhibitor

;

Nitric oxide

;

Arginine

;

Animal

;

Rat

;

Psychosis

;

Mots-clés français / French Keywords

Enzyme

;

Oxidoreductases

;

Vertebrata

;

Mammalia

;

Rodentia

;

Aminoacide

;

Neuroleptique

;

Psychotrope

;

Traitement

;

Chimiothérapie

;

Nitric-oxide synthase

;

Inhibiteur enzyme

;

Azote monoxyde

;

Arginine

;

Animal

;

Rat

;

Psychose

;

Mots-clés espagnols / Spanish Keywords

Enzima

;

Oxidoreductases

;

Vertebrata

;

Mammalia

;

Rodentia

;

Aminoácido

;

Neuroléptico

;

Psicotropo

;

Tratamiento

;

Quimioterapia

;

Nitric-oxide synthase

;

Inhibidor enzima

;

Nitrógeno monóxido

;

Arginina

;

Animal

;

Rata

;

Psicosis

;

Localisation / Location

INIST-CNRS, Cote INIST : 18217, 35400010222694.0040

Nº notice refdoc (ud4) : 13460412



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