Titre du document / Document title
Role of nitric oxide in experimental models of psychosis in rats
Auteur(s) / Author(s)
GUPTA M. (1) ;
BALAKRISHNAN S. (1) ;
PANDHI P. (1) ;
Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
(1) Department of Pharmacology, Postgraduate Institute of Medical Education & Research, Chandigarh, INDE
Résumé / Abstract
The aim of our study was to investigate the effects of the NO precursor L-arginine and the nitric oxide synthase inhibitor N
ω-nitro-L-arginine (L-NORAG) on amphetamine-induced stereotypy, haloperidol-induced catalepsy and conditioned avoidance response (CAR) in rats. Amphetamine (3 mg/kg i.p.) was used for the induction of stereotypy, while for the induction of catalepsy and CAR, haloperidol (2 mg/kg i.p.) was used. This study was divided into 2 parts-acute administration of L-arginine (150 mg/kg i.p.) and L-NOARG (50 mg/kg i.p.) and chronic administration of L-arginine (150 mg/kg/day i.p.) and L-NOARG (50 mg/kg/day i.p.) for 5 days. We found that L-arginine inhibited amphetamine-induced stereotypy and haloperidolinduced catalepsy, but intensified CAR. On the other hand, L-NOARG intensified stereotypy and catalepsy but inhibited CAR. Also, there was no significant difference between the scores of acute and chronic administration of L-arginine and L-NOARG. It is concluded from our study that nitric oxide produces conflicting results on various models of psychosis. L-arginine might be useful as an antipsychotic without causing extrapyramidal symptoms.
Revue / Journal Title
Methods and findings in experimental and clinical pharmacology
ISSN
0379-0355
Source / Source
2001, vol. 23, n
o9, pp. 497-500 (16 ref.)
Langue / Language
Anglais
Editeur / Publisher
Prous, Barcelona, ESPAGNE
(1979)
(Revue)
Mots-clés anglais / English Keywords
;
;
;
;
;
;
;
;
;
;
;
;
;
;
;
;
;
Mots-clés français / French Keywords
;
;
;
;
;
;
;
;
;
;
;
;
;
;
;
;
;
Mots-clés espagnols / Spanish Keywords
;
;
;
;
;
;
;
;
;
;
;
;
;
;
;
;
;
Localisation / Location
INIST-CNRS, Cote INIST : 18217, 35400010222694.0040
Nº notice refdoc (ud4) : 13460412
