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Titre du document / Document title

A new HPLC method for the determination of etodolac in plasma and its application in bioavailability and pharmacokinetic studies

Auteur(s) / Author(s)

ETMAN Mohamed A. (1) ; SALAMA Rania O. (1) ; SHAMS EL-DEEN Mohamed A. (1) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Department of Pharmaceutics, Faculty of Pharmacy, University of Alexandria, Alexandria, EGYPTE

Résumé / Abstract

A simple, rapid, specific and sensitive reversed-phase high performance liquid chromatographic method for the determination of etodolac in plasma has been developed. Each analysis took no more than 4.5 min and the detection limit was 0.5 μg mL-1. The developed method was applied for determination of the bioavailability and pharmacokinetic parameters of etodolac in human plasma after its administration by two different routes. The obtained pharmacokinetic parameters include AUC, tmax, cmax and t1/2. Peak plasma concentrations were 6.2 and 20.6 μg mL-1 following rectal and oral administration of the drug, respectively. The bioavailability of suppositories, compared to capsules, was found to be 66.0%. The developed method possessed enough specificity and sensitivity required to monitor etodolac in human plasma. In addition to etodolac, the method could be used for the detection of five other NSAIDs, namely, diclofenac, sulindac, piroxicam, indomethacin and ketoprofen.

Revue / Journal Title

Acta pharmaceutica    ISSN  1330-0075 

Source / Source

2001, vol. 51, no4, pp. 297-303 (16 ref.)

Langue / Language

Anglais

Editeur / Publisher

Hrvatsko farmaceutsko društvo, Zagreb, CROATIE  (1992) (Revue)

Mots-clés anglais / English Keywords

Hard capsule

;

Suppository

;

Rectal administration

;

Oral administration

;

Healthy subject

;

Human

;

Bioavailability

;

Pharmacokinetics

;

Blood plasma

;

HPLC chromatography

;

Quantitative analysis

;

Non steroidal antiinflammatory agent

;

Etodolac

;

Mots-clés français / French Keywords

Gélule

;

Suppositoire

;

Voie rectale

;

Voie orale

;

Individu sain

;

Homme

;

Biodisponibilité

;

Pharmacocinétique

;

Plasma sanguin

;

Chromatographie HPLC

;

Analyse quantitative

;

Antiinflammatoire non stéroïde

;

Etodolac

;

Mots-clés espagnols / Spanish Keywords

Cápsula dura

;

Supositorio

;

Vía rectal

;

Vía oral

;

Individuo sano

;

Hombre

;

Biodisponibilidad

;

Farmacocinética

;

Plasma sanguíneo

;

Cromatografía HPLC

;

Análisis cuantitativo

;

Antiinflamatorio no esteroide

;

Etodolaco

;

Localisation / Location

INIST-CNRS, Cote INIST : 7013, 35400010326743.0060

Nº notice refdoc (ud4) : 13433075



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