Titre du document / Document title

Malignità : Trattamento e prognosi delle Neoplasie Endocrine Gastrointestinali e del Pancreas: studio retrospettivo su una serie di 16 casi. Commento = Malignancy treatment and prognosis of endocrine tumours of gastrointestinal tract and pancreas: A retrospective study about 16 cases. Commentary

Auteur(s) / Author(s)

PANSINI G. C. ; LANZARA S. ; FEO C. V. ; ZAMBONI P. ; LIBONI A. ; AMBROSIO M. R. ; MARZOLA A. ; FEGGI L. ; MARRANO Domenico ;

Résumé / Abstract

The aim of this study was to review our experience with endocrine tumours of the gastrointestinal tract and pancreas (ETGIP). Between February 1991 and March 2000, sixteen patients with ETGIP were operated on at our institution. Of these patients we reviewed preoperative symptoms, diagnostic techniques (ultrasound, CT, MRI, radio belled octreotide scintigraphy, angiography, immunohistochemical study), treatment (surgical operation, neoadjuvant and adjuvant chemotherapy, and radiometabolic therapy) and survival. Nine patients (56%) had a carcinoid tumour, three (19%) an unspecified endocrine tumour, and four (25%) an endocrine tumour associated with a non-endocrine neoplasm. Only five patients (31%) had a preoperative diagnosis of endocrine tumour. Eight patients (50%) had metastatic disease at the time of the operation. All patients without preoperative metastasis (eight patients, 50%) are still alive without recurrent disease, with a mean postoperative survival of 36 months (12-60 months). Of eight patients with metastatic disease, six (75%) died after a mean of 20.5 months (3-60 months) and two (25%) are still alive with the disease after 3 and 6 months, respectively. These data show that presence of metastasis strongly influence survival. Furthermore, survival of patients with metastatic disease seems to be longer as compared to other gastrointestinal tract malignancies. ETGIP are more common and aggressive than previously believed and, therefore, early diagnosis is crucial for cure. Nowadays, however, new diagnostic tools such as radiolabelled octreotide scintigraphy are available for diagnosis and postoperative follow-up. The optimal treatment or ETGIP is a multimodal approach with surgical operation, chemoradiation, radiometabolic, and genetic therapies.

Revue / Journal Title

Annali Italiani di chirurgia   ISSN 0003-469X 

Source / Source

2001, vol. 72, n^o4, pp. 413-422 [10 page(s) (article)]

Langue / Language

Italien
Revue : Italien

Editeur / Publisher

Cappelli, Bologna, ITALIE  (1922) (Revue)

Localisation / Location

INIST-CNRS, Cote INIST : 3755, 35400010357540.0030