Titre du document / Document title
Differentiated approaches to the treatment of pregnant women at risk of intrauterine fetal infection
Auteur(s) / Author(s)KACHALINA T. S.
KATKOVA N. Yu.
GRECHKANEV G. O.
Résumé / Abstract
Purpose: To detect the effects of medical ozone exposure as a component of combined therapy of pregnant patients at risk of intrauterine fetal infection and to develop differentiated approaches to therapy of this patient population. Methodology: Prospective and retrospective study. Setting: Department of Obstetrics and Gynecology, Nizhny Novgorod State Medical Academy. Subjects: 122 patients at risk of intrauterine infection at 22-36 weeks gestation. Group 1) 60 patients with chronic foci of extragenital infection; 2) 45 women with chronic foci of genital infection; 3) 17 patients with chronic genital infections with exacerbations during the current pregnancy and aggravated obstetrical history. Main (with medical ozone exposure) and control (traditional therapy) subgroups were distinguished in each group. Methods: Primary and final products of lipid peroxidation (dienic conjugates, Schiff bases, total antioxidant activity of the blood evaluated by the fluorescent method) were measured. Blood concentrations of estriol and placental lactogen were measured using standard kits. Ultrasonic examination and microbiological investigation (by polymerase chain reaction) were carried out. In immunological studies blood T and B lymphocytes and their subpopulations were assayed using monoclonal antibodies, the levels of immune complexes circulation and immunoglobulins A, M, and G were measured. The results were statistically processed using MEDST software. Results: In group 1 exposure to medical ozone decreased the levels of primary and final products of lipid peroxidation by 40%, increased serum total antioxidant activity by 44%, normalized immune parameters, restored the hormone balance of the fetoplacental system and uteroplacental bloodflow, and hence, improved the course of pregnancy, labor, and the perinatal period. In group 2 positive changes in the studied parameters were observed in patients treated with immunocorrective drugs. In group 3 no normalization of the studied parameters was attained either by medical ozone exposure or by traditional therapy. Conclusion: Medical ozone exposure is effective in combined prophylactic treatment and therapy of intrauterine infection in women with chronic extragenital infections. Immunocorrective drug treatment is preferable in patients with chronic genital infections. Patients with chronic genital infections and aggravated obstetrical and gynecological history should be treated before pregnancy.
Revue / Journal TitleAkušerstvo i ginekologiâ
Source / Source
5, pp. 19-24 [6 page(s) (article)]
Langue / Language
Editeur / Publisher
Medicina, Moskva, RUSSIE, FEDERATION DE
Localisation / Location
INIST-CNRS, Cote INIST : 2212, 35400010326503.0060
Nº notice refdoc (ud4) : 13429175