Titre du document / Document title

Can HIV-1-contaminated syringes be disinfected? Implications for transmission among injection drug users

Auteur(s) / Author(s)

ABDALA Nadia ⁽¹⁾ ; GLEGHORN Alice A. ⁽²⁾ ; CARNEY John M. ⁽¹⁾ ; HEIMER Robert ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut, ETATS-UNIS
⁽²⁾ Community Substance Abuse Services, San Francisco Department of Public Health, San Francisco, California, ETATS-UNIS

Résumé / Abstract

Bleaching of syringes has been advocated to prevent HIV- 1 transmission among injection drug users (IDUs). Bleach is frequently distributed by needle exchange, outreach, and educational programs targeting IDUs. We applied a sensitive HIV-I microculture assay to determine the effectiveness of bleach in disinfecting syringes contaminated with HIV-1 This study demonstrates that in a laboratory environment designed to replicate injection behaviors, undiluted bleach is highly effective in reducing the viability of HIV-1 even after minimal contact time. However, it did not reduce the HIV-1 recovery to zero. Furthermore, three washes with water were nearly as effective as a single rinse with undiluted bleach in reducing the likelihood that contaminated syringes harbored viable HIV-1 Given the reality that IDUs share syringes and may not have access to a new, sterile syringe for each injection, the results suggest that they should be encouraged through harm reduction interventions to clean their syringes, preferably with undiluted bleach.

Revue / Journal Title

Journal of acquired immune deficiency syndromes   ISSN 1525-4135 

Source / Source

2001, vol. 28, n^o5, pp. 487-494 (31 ref.)

Langue / Language

Anglais

Editeur / Publisher

Lippincott Williams & Wilkins, Hagerstown, MD, ETATS-UNIS  (1999) (Revue)

Mots-clés anglais / English Keywords

Virus ; Retroviridae ; Lentivirus ; Human immunodeficiency virus ; Replication ; Sensitivity ; Targeting ; Drug addiction ; Transmission ; Contamination ; HIV-1 virus ;

Mots-clés français / French Keywords

Virus ; Retroviridae ; Lentivirus ; Virus immunodéficience humaine ; Réplication ; Sensibilité ; Ciblage ; Toxicomanie ; Transmission ; Contamination ; Virus HIV1 ;

Mots-clés espagnols / Spanish Keywords

Virus ; Retroviridae ; Lentivirus ; Human immunodeficiency virus ; Replicación ; Sensibilidad ; Blancado ; Toxicomanía ; Transmisión ; Contaminación ; HIV-1 virus ;

Localisation / Location

INIST-CNRS, Cote INIST : 21576, 35400009474025.0130