Titre du document / Document title
Antiproliferative constituents in the plant 8. Seeds of Rhynchosia volubilis
Auteur(s) / Author(s)
KINJO Junei (1) ;
NAGAO Tsuneatsu (1) ;
TANAKA Takashi (2) ;
NONAKA Gen-Ichiro (3) ;
OKABE Hikaru (1) ;
Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
(1) Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, JAPON
(2) School of Pharmaceutical Sciences, Nagasaki University, 1-14 Bunkyomachi, Nagasaki 852-8521, JAPON
(3) Usaien Pharm. Co., Ltd., 1-3-17 Zaimoku, Saga 840-0055, JAPON
Résumé / Abstract
The MeOH extract of the seeds of Rhynchosia volubilis (Leguminosae) showed antiproliferative activity against human gastric adenocarcinoma [MK-1, 50% growth inhibition (GI
50): 25 μg/ml], human uterus carcinoma (HeLa, GI
50: 30 μg/ml), and murine melanoma (B16F10, GI
50: 8 μg/ml) cells. Bioactivity-guided fractionation resulted in the isolation of gallic acid methylester (1), gallic acid (2), 7-O-galloylcatechin (3), 1,6-di-O-galloylglucose (4), 1-O-galloylglucose (5), and trigalloylgallic acid (6), and their antiproliferative activity was estimated. All showed much stronger inhibition against B16F10 cell growth than against HeLa and MK-1 cell growth. Compound 2 and its tetramer (6) with a free carboxyl group showed higher activity than those which did not have a free carboxyl group. In relation to the gallic acid tetramer (6), two gallic acid dimers (ellagic acid and dehydrodigallic acid) and trimers (tergallic acid dilactone and flavogallonic acid dilactone) were tested for their activity, and compared with those of the isolates.
Revue / Journal Title
Biological & pharmaceutical bulletin
ISSN
0918-6158
Source / Source
2001, vol. 24, n
o12, pp. 1443-1445 (14 ref.)
Langue / Language
Anglais
Editeur / Publisher
Pharmaceutical Society of Japan, Tokyo, JAPON
(1993)
(Revue)
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Localisation / Location
INIST-CNRS, Cote INIST : 18096, 35400010320654.0240
Nº notice refdoc (ud4) : 13400364
