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Titre du document / Document title

Antiproliferative constituents in the plant 8. Seeds of Rhynchosia volubilis

Auteur(s) / Author(s)

KINJO Junei (1) ; NAGAO Tsuneatsu (1) ; TANAKA Takashi (2) ; NONAKA Gen-Ichiro (3) ; OKABE Hikaru (1) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, JAPON
(2) School of Pharmaceutical Sciences, Nagasaki University, 1-14 Bunkyomachi, Nagasaki 852-8521, JAPON
(3) Usaien Pharm. Co., Ltd., 1-3-17 Zaimoku, Saga 840-0055, JAPON

Résumé / Abstract

The MeOH extract of the seeds of Rhynchosia volubilis (Leguminosae) showed antiproliferative activity against human gastric adenocarcinoma [MK-1, 50% growth inhibition (GI50): 25 μg/ml], human uterus carcinoma (HeLa, GI50: 30 μg/ml), and murine melanoma (B16F10, GI50: 8 μg/ml) cells. Bioactivity-guided fractionation resulted in the isolation of gallic acid methylester (1), gallic acid (2), 7-O-galloylcatechin (3), 1,6-di-O-galloylglucose (4), 1-O-galloylglucose (5), and trigalloylgallic acid (6), and their antiproliferative activity was estimated. All showed much stronger inhibition against B16F10 cell growth than against HeLa and MK-1 cell growth. Compound 2 and its tetramer (6) with a free carboxyl group showed higher activity than those which did not have a free carboxyl group. In relation to the gallic acid tetramer (6), two gallic acid dimers (ellagic acid and dehydrodigallic acid) and trimers (tergallic acid dilactone and flavogallonic acid dilactone) were tested for their activity, and compared with those of the isolates.

Revue / Journal Title

Biological & pharmaceutical bulletin    ISSN  0918-6158 

Source / Source

2001, vol. 24, no12, pp. 1443-1445 (14 ref.)

Langue / Language

Anglais

Editeur / Publisher

Pharmaceutical Society of Japan, Tokyo, JAPON  (1993) (Revue)

Mots-clés anglais / English Keywords

Spermatophyta

;

Angiospermae

;

Dicotyledones

;

Structure activity relation

;

Cytotoxicity

;

Cell proliferation

;

Interspecific comparison

;

Animal origin

;

Human origin

;

Established cell line

;

Tumor cell

;

In vitro

;

Biological activity

;

Seeds

;

Antineoplastic agent

;

Pharmacognosy

;

Medicinal plant

;

Plant origin

;

Leguminosae

;

Mots-clés français / French Keywords

Spermatophyta

;

Angiospermae

;

Dicotyledones

;

Rhynchosia volubilis

;

Lignée HELA

;

Relation structure activité

;

Cytotoxicité

;

Multiplication cellulaire

;

Comparaison interspécifique

;

Origine animale

;

Origine humaine

;

Lignée cellulaire établie

;

Cellule tumorale

;

In vitro

;

Activité biologique

;

Graine

;

Anticancéreux

;

Pharmacognosie

;

Plante médicinale

;

Origine végétale

;

Leguminosae

;

Mots-clés espagnols / Spanish Keywords

Spermatophyta

;

Angiospermae

;

Dicotyledones

;

Relación estructura actividad

;

Citotoxicidad

;

Multiplicación celular

;

Comparación interespecífica

;

Origen animal

;

Origen humano

;

Línea celular establecida

;

Célula tumoral

;

In vitro

;

Actividad biológica

;

Semillas

;

Anticanceroso

;

Farmacognosia

;

Planta medicinal

;

Origen vegetal

;

Leguminosae

;

Localisation / Location

INIST-CNRS, Cote INIST : 18096, 35400010320654.0240

Nº notice refdoc (ud4) : 13400364



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