Titre du document / Document title

Low serum testosterone level as a predictor of increased visceral fat in Japanese-American men

Auteur(s) / Author(s)

TSAI E. C. ⁽¹⁾ ; BOYKO E. J. ^{(1 2)} ; LEONETTI D. L. ⁽³⁾ ; FUJIMOTO W. Y. ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Department of Medicine, University of Washington, Seattle, WA, ETATS-UNIS
⁽²⁾ The Seattle Epidemiologic Research and Information Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, ETATS-UNIS
⁽³⁾ Department of Anthropology, University of Washington, Seattle, WA, ETATS-UNIS

Résumé / Abstract

OBJECTIVE: To examine the association between baseline testosterone levels and changes in visceral adiposity in Japanese-American men. DESIGN: Prospective observational study. SUBJECTS: Second-generation Japanese-American males enrolled in a community-based population study. MEASUREMENTS: At baseline, 110 men received a 75 g oral glucose tolerance test (OGTT), and an assessment of body mass index (BMI); visceral adiposity measured as intra-abdominal fat area (IAF) using computed tomography (CT); fasting insulin and C-peptide levels; and total testosterone levels. IAF was re-measured after 7.5 y. Subcutaneous fat areas were also measured by CT in the abdomen, thorax and thigh. The total fat (TF) was calculated as the sum of IAF and total subcutanous fat areas (SCF). RESULTS: After 7.5y, IAF increased by a mean of 8.0 cm² (95% Cl: 0.8, 15.3). Baseline total testosterone was significantly correlated with change in IAF (r=-0.26, P=0.006), but not to any appreciable degree with change in BMI, TF, or SCF. In a linear regression model with change in IAF as the dependent variable, baseline testosterone was significantly related to this outcome while adjusting for baseline IAF, SCF, BMI, age, diabetes mellitus status (OGTT by the WHO diagnostic criteria) and fasting C-peptide (regression coefficient for baseline testosterone [nmol/l] = -107.13, P = 0.003]. CONCLUSIONS: In this Japanese-American male cohort, lower baseline total testosterone independently predicts an increase in IAF. This would suggest that by predisposing to an increase in visceral adiposity, low levels of testosterone may increase the risk of type 2 diabetes mellitus.

Revue / Journal Title

International journal of obesity   ISSN 0307-0565   CODEN IJOBDP 

Source / Source

2000, vol. 24, n^o4, pp. 485-491 (51 ref.)

Langue / Language

Anglais

Editeur / Publisher

Nature Publishing, Basingstoke, ROYAUME-UNI  (1977) (Revue)

Mots-clés anglais / English Keywords

Visceral obesity ; Evolution ; Testosterone ; Hormonal investigation ; Blood plasma ; Non insulin dependent diabetes ; Risk factor ; Comparative study ; Obesity ; Adult ; Elderly ; Mongoloid ; Nutritional status ; Human ; Androgen ; Testicular hormone ; Sex steroid hormone ; Endocrinopathy ; Nutrition disorder ;

Mots-clés français / French Keywords

Obésité viscérale ; Evolution ; Testostérone ; Exploration hormonale ; Plasma sanguin ; Diabète non insulinodépendant ; Facteur risque ; Etude comparative ; Obésité ; Adulte ; Personne âgée ; Mongoloïde ; Etat nutritionnel ; Homme ; Androgène ; Hormone testiculaire ; Hormone stéroïde sexuelle ; Endocrinopathie ; Trouble nutrition ;

Mots-clés espagnols / Spanish Keywords

Obesidad visceral ; Evolución ; Testosterona ; Análisis hormonal ; Plasma sanguíneo ; Diabetes no insulinodependiente ; Factor riesgo ; Estudio comparativo ; Obesidad ; Adulto ; Anciano ; Mongoloide ; Estado nutricional ; Hombre ; Andrógeno ; Hormona testicular ; Hormona esteroide sexual ; Endocrinopatía ; Trastorno nutricíon ;

Localisation / Location

INIST-CNRS, Cote INIST : 18243, 35400008742554.0130