Titre du document / Document title

The Pro12Ala variant of peroxisome proliferator-activated receptor-γ2 (PPAR-γ2) is associated with measures of obesity in Mexican Americans

Auteur(s) / Author(s)

COLE S. A. ⁽¹⁾ ; MITCHELL B. D. ⁽¹⁾ ; HSUEH W.-C. ⁽¹⁾ ; PINEDA P. ⁽¹⁾ ; BEAMER B. A. ⁽²⁾ ; SHULDINER A. R. ⁽³⁾ ; COMUZZIE A. G. ⁽¹⁾ ; BLANGERO J. ⁽¹⁾ ; HIXSON J. E. ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Southwest Foundation for Biomedical Research, PO Box 760549, San Antonio, TX 78245, ETATS-UNIS
⁽²⁾ Johns Hopkins University School of Medicine; Geriatrics Center, 5505 Hopkins Bayview Circle, Baltimore, MD 21224, ETATS-UNIS
⁽³⁾ University of Maryland School of Medicine and the Baltimore Veterans Administration Medical Center Geriatrics Research and Education Clinical Center, 725 West Lombard St., Baltimore, MD 21201, ETATS-UNIS

Résumé / Abstract

Peroxisome proliferator-activated receptors (PPAR) are transcription factors that regulate adipocyte differentiation and gene expression. We tested the hypothesis that the Pro12Ala variant of PPAR-y2 is associated with obesity and type 2 diabetes-related traits in 921 subjects from the San Antonio Family Heart Study. Subjects with at least one Ala allele (n=210) had significantly higher body mass index (P=0.015) and waist circumference (P=0.028) and significantly higher levels of serum leptin (P=0.022) than those without the allele. Further studies will determine whether the Pro12Ala variant itself, or other genetic variation at PPAR-γ, is responsible for this association with measures of obesity in Mexican Americans.

Revue / Journal Title

International journal of obesity   ISSN 0307-0565   CODEN IJOBDP 

Source / Source

2000, vol. 24, n^o4, pp. 522-524 (14 ref.)

Langue / Language

Anglais

Editeur / Publisher

Nature Publishing, Basingstoke, ROYAUME-UNI  (1977) (Revue)

Mots-clés anglais / English Keywords

Obesity ; Genetic determinism ; Peroxisome proliferator ; Nuclear receptor ; Transcription factor ; Genotype ; Comparative study ; Body mass index ; Adult ; Nutritional status ; Human ; Nutrition disorder ;

Mots-clés français / French Keywords

Obésité ; Déterminisme génétique ; Proliférateur peroxysome ; Récepteur nucléaire ; Facteur transcription ; Génotype ; Etude comparative ; Indice masse corporelle ; Adulte ; Etat nutritionnel ; Homme ; Trouble nutrition ;

Mots-clés espagnols / Spanish Keywords

Obesidad ; Determinismo genético ; Proliferador peroxisoma ; Receptor nuclear ; Factor transcripción ; Genotipo ; Estudio comparativo ; Indice masa corporal ; Adulto ; Estado nutricional ; Hombre ; Trastorno nutricíon ;

Localisation / Location

INIST-CNRS, Cote INIST : 18243, 35400008742554.0200