Titre du document / Document title

Copper allergy revisited

Auteur(s) / Author(s)

WÖHRL Stefan ⁽¹⁾ ; HEMMER Wolfgang ⁽¹⁾ ; FOCKE Margarete ⁽¹⁾ ; GÖTZ Manfred ^{(1 2)} ; JARISCH Reinhart ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ FAZ-Floridsdorf Allergy Centre, AUTRICHE
⁽²⁾ Department of Pediatrics, Wilhelminenspital, AUTRICHE

Résumé / Abstract

Background: Positive patch tests to copper sulfate are regularly observed, although copper is reported as a rare allergen with a low sensitizing potential. Usually they are claimed to be irritant and unspecific. Objective: The aim of this study was to assess the relevance and the diagnostic value of positive reactions to copper. Methods: A total of 2660 routine patch tests were analyzed for positive reactions to copper and other metal allergens: copper, 3.53%; nickel, 21.02%; palladium, 5.90%; cobalt, 3.31%. Results: Reactions to copper and nickel were highly significantly associated with each other. Twenty-six patients with a positive routine test to copper were retested. The reproducibility was modest (38%), but again significantly associated with nickel sensitization. Conclusion: These clinical data support a copper-nickel cross-reactivity concept on T-cell level based on recently published molecular data. We conclude that positive patch tests to copper are mostly specific; however, they are usually of low clinical relevance.

Revue / Journal Title

Journal of the American Academy of Dermatology   ISSN 0190-9622   CODEN JAADDB 

Source / Source

2001, vol. 45, n^o6, pp. 863-870 (43 ref.)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, New York, NY, ETATS-UNIS  (1979) (Revue)

Mots-clés anglais / English Keywords

Immunopathology ; Skin disease ; Nickel ; Skin test ; Human ; Contact dermatitis ; Copper ; Allergy ;

Mots-clés français / French Keywords

Immunopathologie ; Peau pathologie ; Nickel ; Test cutané ; Homme ; Dermatite contact ; Cuivre ; Allergie ;

Mots-clés espagnols / Spanish Keywords

Inmunopatología ; Piel patología ; Niquel ; Prueba cutáneo ; Hombre ; Dermatitis de contacto ; Cobre ; Alergia ;

Localisation / Location

INIST-CNRS, Cote INIST : 18387, 35400009426207.0080