Titre du document / Document title

Follicular lymphoma : Have we made any progress?

Auteur(s) / Author(s)

HORNING S. J. ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Department of Medicine (Oncology and Bone Marrow Transplantation), Stanford University Medical Center, Stanford, CA, ETATS-UNIS

Résumé / Abstract

Follicular lymphomas are characterized by relatively long median survivals and a continuous pattern of relapse. The heterogeneity in these diseases is increasingly appreciated, leading to concerted efforts to define prognostic factors and risk-adapted strategies. The status of multiple options for treatment including interferon, fludarabine, dose intensification with autologous transplantation, therapy targeting the CD20 antigen and novel approaches is reviewed. The long natural history of follicular lymphoma requires mature data for accurate analysis. However, the achievement of molecular remission as a surrogate endpoint is under active investigation. This is an exciting era for the clinical investigation of follicular lymphoma given the large number of candidate therapies and their potential combinations and permutations. Although the goal of primary treatment remains durable remission and cure, the sequential application of effective, non-cross-resistant treatments may also result in a prolongation of median survival time. It is essential that physicians treating patients with follicular lymphoma demonstrate restraint in the application of new treatments and cooperate in the study of new therapies in carefully designed phase II and phase III trials.

Revue / Journal Title

Annals of oncology   ISSN 0923-7534 

Source / Source

Congrès
International Conference on Malignant Lymphoma N^o7, Lugano , SUISSE (02/06/1999)
2000, vol. 11, SUP1 (153 p.)  (34 ref.), [Notes: Selected papers], pp. 23-27

Langue / Language

Anglais

Editeur / Publisher

Oxford University Press, Oxford, ROYAUME-UNI  (1990) (Revue)

Mots-clés anglais / English Keywords

Follicular lymphoma ; Human ; Interferon ; Fludarabine ; Rituximab ; Chemotherapy ; Treatment ; Antineoplastic agent ; Immunotherapy ; Graft ; Bone marrow ; Stem cell ; Antibody ; Purine nucleotide ; Malignant hemopathy ; Lymphoproliferative syndrome ; Non Hodgkin lymphoma ;

Mots-clés français / French Keywords

Lymphome folliculaire ; Homme ; Interféron ; Fludarabine ; Rituximab ; Chimiothérapie ; Traitement ; Anticancéreux ; Immunothérapie ; Greffe ; Moelle osseuse ; Cellule souche ; Anticorps ; Purine nucléotide ; Antigène CD20 ; Hémopathie maligne ; Lymphoprolifératif syndrome ; Lymphome non hodgkinien ;

Mots-clés espagnols / Spanish Keywords

Linfoma folicular ; Hombre ; Interferón ; Fludarabina ; Rituximab ; Quimioterapia ; Tratamiento ; Anticanceroso ; Inmunoterapia ; Injerto ; Médula ósea ; Célula primitiva ; Anticuerpo ; Purina nucleótido ; Hemopatía maligna ; Linfoproliferativo síndrome ; Linfoma no Hodgkin ;

Localisation / Location

INIST-CNRS, Cote INIST : 22429, 35400008657596.0040