Titre du document / Document title

Efficacy and side effects of tramadol versus oxycodone for patient-controlled analgesia after maxillofacial surgery

Auteur(s) / Author(s)

SILVASTI M. ⁽¹⁾ ; TARKKILA P. ⁽²⁾ ; TUOMINEN M. ⁽³⁾ ; SVARTLING N. ⁽¹⁾ ; ROSENBERG P. H. ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Department of Anaesthesia, Töölö Hospital, Helsinki University Central Hospital, FINLANDE
⁽²⁾ Department of Anaesthesia, ENT Hospital, Helsinki University Central Hospital, FINLANDE
⁽³⁾ Department of Anaesthesia, Surgical Hospital, Helsinki University Central Hospital, FINLANDE

Résumé / Abstract

Tramadol, a weak opioid μ-receptor agonist, may have a favourable potency and side effect profile for intravenous patient-controlled analgesia (PCA). In a prospective, double-blind, randomized study involving 54 patients, tramadol was compared with oxycodone in PCA after maxillofacial surgery. All the patients were given diclofenac sodium 1 mg kg^-1 intramuscularly and dexamethasone 8mg twice a day. Post-operatively patients received tramadol or oxycodone by a PCA apparatus (lockout 5 min, tramadol 0.3 mg kg^-1 bolus, oxycodone 0.03 mg kg^-1 bolus). During the immediate recovery period, opioid was administered i.v. in a double-blind fashion, either tramadol 10 mg or oxycodone 1 mg increments until the pain control was judged to be satisfactory by the patient. Pain was assessed at rest and during activity (mouth opening) before and after loading, at 2 h after commencing the PCA, as well as at 21.00 and at 09.00 hours on the following morning. Side effects were recorded. The potency ratio of tramadol to oxycodone was found to be approximately 8:1. There was no significant difference between the groups in the VAS scores for pain. No respiratory depression was identified. Tramadol was found to provide adequate analgesia after maxillofacial surgery without risk of respiratory depression. However, the incidence of nausea was slightly greater in the tramadol group than in the oxycodone group (44% vs. 28%, NS).

Revue / Journal Title

European journal of anaesthesiology   ISSN 0265-0215   CODEN EJANEG 

Source / Source

Congrès
Canadian Anaesthetists' Society. Annual Meeting N^o55, Toronto , CANADA (12/06/1998)
1999, vol. 16, n^o12, pp. 834-839 (18 ref.)

Langue / Language

Anglais

Editeur / Publisher

Cambridge University Press, Cambridge, ROYAUME-UNI  (1984) (Revue)

Mots-clés anglais / English Keywords

Maxillofacial ; Surgery ; Tramadol ; Oxycodone ; Narcotic analgesic ; Analgesic ; Comparative study ; Pain ; Postoperative ; Chemotherapy ; Treatment ; Human ; Intravenous administration ; Self administration ; Analgesia ; Opiates ; Diseases of the osteoarticular system ;

Mots-clés français / French Keywords

Maxillofacial ; Chirurgie ; Tramadol ; Oxycodone ; Analgésique narcotique ; Analgésique ; Etude comparative ; Douleur ; Postopératoire ; Chimiothérapie ; Traitement ; Homme ; Voie intraveineuse ; Autoadministration ; Analgésie ; Opiacés ; Système ostéoarticulaire pathologie ;

Mots-clés espagnols / Spanish Keywords

Maxilofacial ; Cirugía ; Tramadol ; Oxicodona ; Analgésico narcotico ; Analgésico ; Estudio comparativo ; Dolor ; Postoperatorio ; Quimioterapia ; Tratamiento ; Hombre ; Vía intravenosa ; Autoadministración ; Analgesia ; Opiados ; Sistema osteoarticular patología ;

Localisation / Location

INIST-CNRS, Cote INIST : 20676, 35400008680465.0030