Titre du document / Document title
Ions, genes and insulin release : from basic science to clinical disease
Auteur(s) / Author(s)
DUNNE M. J.
(1) ;
Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
(1) Institute of Molecular Physiology and Department of Biomedical Science, Sheffield University, Western Bank, Sheffield, ROYAUME-UNI
Résumé / Abstract
In 1968, reports of the first microelectrode recordings of insulin-secreting cells were published. Thirty years later it is now established that electrical responses of β-cells play a critical role in stimulus-secretion coupling. It is now also clear that defects in ion channel genes compromise the mechanisms which govern secretion and lead to the onset of disease. Here, the physiology of insulin release is reviewed in the context of ion channels, the ionic control of insulin release and the pathophysiology of hyperinsulinism of infancy.
Revue / Journal Title
Diabetic medicine
ISSN 0742-3071
CODEN DIMEEV
Source / Source
2000, vol. 17, n
o2, pp. 91-104 (113 ref.)
Langue / Language
Anglais
Editeur / Publisher
Blackwell, Oxford, ROYAUME-UNI
(1984)
(Revue)
Mots-clés anglais / English Keywords
Diabetes mellitus ;
Hyperinsulinemia ;
Hypoglycemia ;
Infant ;
Pathogenesis ;
Insulin ;
Endocrine secretion ;
Ionic channel ;
Genetic determinism ;
Mutation ;
Human ;
Endocrinopathy ;
Pancreatic hormone ;
Mots-clés français / French Keywords
Diabète ;
Hyperinsulinémie ;
Hypoglycémie ;
Nourrisson ;
Pathogénie ;
Insuline ;
Sécrétion endocrine ;
Canal ionique ;
Déterminisme génétique ;
Mutation ;
Homme ;
Endocrinopathie ;
Hormone pancréatique ;
Mots-clés espagnols / Spanish Keywords
Diabetes ;
Hiperinsulinemia ;
Hipoglicemia ;
Lactante ;
Patogenia ;
Insulina ;
Secreción endocrina ;
Canal iónico ;
Determinismo genético ;
Mutación ;
Hombre ;
Endocrinopatía ;
Hormona pancreática ;
Localisation / Location
INIST-CNRS, Cote INIST : 20274, 35400008680978.0010
Nº notice refdoc (ud4) : 1292434
