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Titre du document / Document title

Effects of the neoflavonoid coutareagenin, one of the antidiabetic active substances of Hintonia latiflora, on streptozotocin-induced diabetes mellitus in rats

Auteur(s) / Author(s)

KOREC R. (1) ; SENSCH K. H. (2) ; ZOUKAS T. (2) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Diabetic Research Laboratory of the Faculty of Medicine of P. J. Šafárik University, Kosice, SLOVAQUIE
(2) Research Laboratory of Gehrlicher, Eurasburg, ALLEMAGNE

Résumé / Abstract

In the present study, diabetes mellitus was induced with streptozotocin in Wistar rats from the inbred strain F > 28, and a blood sugar lowering effect due to the oral or intragastric administration of a copalchi native extract (Hintoniae latiflorae cortex) or intragastric administration of the pure substance, coutareagenin (neoflavonoid) (5-hydroxy-7-methoxy-4-(3,4-dihydroxyphenyl)-2H-benzo-1-pyran-2-on), was demonstrated with statistically significant results. This study enlarged and confirmed the results of earlier studies by other authors with regard to the antidiabetic effect of the copalchi bark extract in various animal species with hyperglycemia induced by different methods. By the use of the synthetically produced neoflavonoid, coutareagenin, the present series of tests provided evidence that coutareagenin, one of the active substances contained in Hintonia latiflora bark (Copalchi bark), produces a reduction of diabetic elevated blood sugar levels. The native extract as a whole, however. has to be regarded as the active substance (active substance complex) of Hintonia latiflora (Copalchi) bark.

Revue / Journal Title

Arzneimittel-Forschung    ISSN  0004-4172   CODEN ARZNAD 

Source / Source

Congrès
Symposium der Paul-Martini-Stiftung in Verbindung mit der Akademie der Wissenschaften und der Literatur, Mainz , ALLEMAGNE (12/11/1999)
2000, vol. 50, no 2, pp. 189-224 (33 ref.), pp. 122-128

Langue / Language

Anglais
Revue : Allemand

Revue : Anglais

Editeur / Publisher

Thieme, Stuttgart, ALLEMAGNE  (1951-2012) (Revue)

Mots-clés anglais / English Keywords

Hypoglycemic agent

;

Phytotherapy

;

Treatment

;

Diabetes mellitus

;

Treatment efficiency

;

Animal

;

Rat

;

Medicinal plant

;

Pharmacognosy

;

Plant origin

;

Copal gum

;

Flavonoid

;

Oral administration

;

Intragastric administration

;

Rodentia

;

Mammalia

;

Vertebrata

;

Endocrinopathy

;

Mots-clés français / French Keywords

Hypoglycémiant

;

Phytothérapie

;

Traitement

;

Diabète

;

Efficacité traitement

;

Animal

;

Rat

;

Plante médicinale

;

Pharmacognosie

;

Origine végétale

;

Gomme copal

;

Flavonoïde

;

Voie orale

;

Voie intragastrique

;

Rodentia

;

Mammalia

;

Vertebrata

;

Endocrinopathie

;

Mots-clés espagnols / Spanish Keywords

Hipoglicemiante

;

Fitoterapia

;

Tratamiento

;

Diabetes

;

Eficacia tratamiento

;

Animal

;

Rata

;

Planta medicinal

;

Farmacognosia

;

Origen vegetal

;

Goma copal

;

Flavonoide

;

Vía oral

;

Vía intragástrica

;

Rodentia

;

Mammalia

;

Vertebrata

;

Endocrinopatía

;

Localisation / Location

INIST-CNRS, Cote INIST : 565, 35400008663529.0040

Nº notice refdoc (ud4) : 1285556



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