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Titre du document / Document title

Effects of an ethanolic extract of Gynura procumbens on serum glucose, cholesterol and triglyceride levels in normal and streptozotocin-induced diabetic rats

Auteur(s) / Author(s)

ZHANG X. F. (1) ; TAN B. K. H. (1) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Department of Pharmacology, National University of Singapore, 10 Kent Ridge Crescent, 119260, SINGAPOUR

Résumé / Abstract

Aim of Study: The aim was to demonstrate the effects of the leaves of Gynura procumbens (Lour.) Merr. on blood sugar and lipid levels in experimental animals. Methodology: We obtained an ethanolic extract of the leaves of G. procumbens and monitored the effects of an oral administration of (i) different single doses of the extract on oral glucose tolerance in streptozotocin-induced diabetic and normal rats and (ii) fourteen doses over 7 days on serum cholesterol and triglyceride levels in streptozotocin-induced diabetic rats. Metformin and glibenclamide were used as positive control drugs. Results: The extract, at single doses of 50, 150 and 300 mg/kg orally, significantly suppressed the elevated serum glucose levels in diabetic rats; 150 mg/kg was found to be the optimum hypoglycaemic dose. The extract however did not significantly suppress the elevated serum glucose levels in normal rats, unlike glibenclamide. Metformin, but not glibenclamide, improved glucose tolerance in the diabetic rats. When the optimum dose was given to diabetic rats for 7 days, the extract significantly reduced serum cholesterol and triglyceride levels in these rats. Conclusion: These results indicate that the leaves of G. procumbens may have biguanide-like activity.

Revue / Journal Title

Singapore medical journal    ISSN  0037-5675   CODEN SIMJA3 

Source / Source

2000, vol. 41, no1, pp. 9-13 (14 ref.)

Langue / Language

Anglais

Editeur / Publisher

Singapore Medical Association, Singapore, SINGAPOUR  (1960) (Revue)

Mots-clés anglais / English Keywords

Ethanol

;

Extract

;

Cholesterol

;

Glucose

;

Triglyceride

;

Blood plasma

;

Diabetes mellitus

;

Experimental disease

;

Influence

;

Oral administration

;

Animal

;

Rat

;

Rodentia

;

Mammalia

;

Vertebrata

;

Hypoglycemic agent

;

Lipids

;

Endocrinopathy

;

Mots-clés français / French Keywords

Ethanol

;

Extrait

;

Cholestérol

;

Glucose

;

Triglycéride

;

Plasma sanguin

;

Diabète

;

Pathologie expérimentale

;

Influence

;

Voie orale

;

Animal

;

Rat

;

Gynura procumbens

;

Rodentia

;

Mammalia

;

Vertebrata

;

Hypoglycémiant

;

Lipide

;

Endocrinopathie

;

Mots-clés espagnols / Spanish Keywords

Etanol

;

Extracto

;

Colesterol

;

Glucosa

;

Triglicérido

;

Plasma sanguíneo

;

Diabetes

;

Patología experimental

;

Influencia

;

Vía oral

;

Animal

;

Rata

;

Rodentia

;

Mammalia

;

Vertebrata

;

Hipoglicemiante

;

Lípido

;

Endocrinopatía

;

Localisation / Location

INIST-CNRS, Cote INIST : 20931, 35400008189582.0020

Nº notice refdoc (ud4) : 1269964



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