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Titre du document / Document title

Cidofovir, a new approach for the treatment of cervix intraepithelial neoplasia grade III (CIN III)

Auteur(s) / Author(s)

SNOECK R. (1) ; NOEL J.-C. (2) ; MULLER C. (3) ; DE CLERCQ E. (1) ; BOSSENS M. (3) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Rega Institute for Medical Research, Leuven, BELGIQUE
(2) Pathology Department, Erasme Hospital, Free University of Brussels, Brussels, BELGIQUE
(3) Gynaecology Department, Centre Hospitalier Etterbeek-Ixelles, Brussels, BELGIQUE

Résumé / Abstract

Cervix intraepithelial neoplasia grade III (CIN III) is an intraepithelial proliferative process with different levels of severity depending on both the extension of the proliferation in the epithelium and the presence of cellular atypia. Human papillomavirus (HPV) has been clearly associated with such lesions. The results of a preliminary study are described on the local application of cidofovir, an acyclic nucleoside phosphonate derivative with broad-spectrum anti-DNA virus activity for the treatment of CIN III. Cidofovir 1% in gel was applied three times, every other day, on the cervix of each of 15 women with biopsy proven CIN III, Within 1 month after the start of treatment, the cervix was removed surgically. Histology and human papillomavirus polymerase chain reaction (HPV-PCR) were carried out. In 7 of the 15 patients the histology showed a complete response, whereas 5 patients had a partial response characterized by the persistence of CIN II-III lesions, 1 patient had a dysplasia of lower grade (CIN I), and 2 patients did not show differences in the histology. Complete response was confirmed by PCR in 4 of the 7 patients, with complete response histologically. Cidofovir was not toxic to the normal epithelium. Cidofovir 1% gel was able to inhibit partially or completely cervical dysplasia lesions after only three applications (every other day). This effect was specific and tissue other than the dysplastic epithelium was not affected by the treatment.

Revue / Journal Title

Journal of medical virology    ISSN  0146-6615   CODEN JMVIDB 

Source / Source

2000, vol. 60, no2, pp. 205-209 (36 ref.)

Langue / Language

Anglais

Editeur / Publisher

Wiley, Hoboken, NJ, ETATS-UNIS  (1977) (Revue)

Mots-clés anglais / English Keywords

Carcinoma

;

Carcinoma in situ

;

Dysplasia

;

Uterine cervix

;

Cidofovir

;

Acyclic nucleoside

;

Colloidal gel

;

Local administration

;

Chemotherapy

;

Treatment

;

Antineoplastic agent

;

Human

;

Malignant tumor

;

Uterine cervix diseases

;

Female genital diseases

;

Mots-clés français / French Keywords

Carcinome

;

Cancer in situ

;

Dysplasie

;

Col utérus

;

Cidofovir

;

Nucléoside acyclique

;

Gel colloïdal

;

Voie locale

;

Chimiothérapie

;

Traitement

;

Anticancéreux

;

Homme

;

Tumeur maligne

;

Col utérus pathologie

;

Appareil génital femelle pathologie

;

Mots-clés espagnols / Spanish Keywords

Carcinoma

;

Carcinoma in situ

;

Displasia

;

Cuello útero

;

Cidofovir

;

Nucleósido acíclico

;

Gel coloidal

;

Vía local

;

Quimioterapia

;

Tratamiento

;

Anticanceroso

;

Hombre

;

Tumor maligno

;

Cuello útero patología

;

Aparato genital hembra patología

;

Localisation / Location

INIST-CNRS, Cote INIST : 17422, 35400008122534.0160

Nº notice refdoc (ud4) : 1265311



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