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Titre du document / Document title

Vitamin A supplementation selectively improves the linear growth of Indonesian preschool children : results from a randomized controlled trial

Auteur(s) / Author(s)

HADI H. ; STOLTZFUS R. J. ; DIBLEY M. J. ; MOULTON L. H. ; WEIST K. P. ; KJOLHEDE C. L. ; SADJIMIN T. ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

Division of Human Nutrition, the Department of Public Health, the Faculty of Medicine, the University of Gadjah Mada, Yogyakarta, INDONESIE
Division of Human Nutrition, the Departments of International Health and Biostatistics, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, ETATS-UNIS
Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, Newcastle, AUSTRALIE

Résumé / Abstract

Background: Vitamin A deficiency is associated with stunting and wasting in preschool children, but vitamin A supplementation trials have not shown a consistent effect on growth. Objective: We examined the effect of vitamin A supplementation on height and weight increments among Indonesian preschool children. Design: Data were obtained from a randomized, double-masked, placebo-controlled trial of rural Javanese children aged 6-48 mo. Children received 206000 IU vitamin A (103000 IU if aged < 12 mo) or placebo every 4 mo. Results: High-dose vitamin A supplementation modestly improved the linear growth of the children by 0.16 cm/4 mo. The effect was modified by age, initial vitamin A status, and breast-feeding status. Vitamin A supplementation improved height by 0.10 cm/4 mo in children aged < 24 mo and by 0.22 cm/4 mo in children aged ≥ 24 mo. The vitamin A-supplemented children with an initial serum retinol concentration <0.35 μmol/L gained 0.39 cm/4 mo more in height and 152 g/4 mo more in weight than did the placebo group. No growth response to vitamin A was found among children with an initial serum retinol concentration ≥ 0.35 μmol/L. In non-breast-fed children, vitamin A supplementation improved height by 0.21 cm/4 mo regardless of age. In breast-fed children, vitamin A supplementation improved linear growth by 0.21 cm/4 mo among children aged ≥24 mo, but had no significant effect on the growth of children aged < 24 mo. Conclusion: High-dose vitamin A supplementation improves the linear growth of children with very low serum retinol and the effect is modified by age and breast-feeding.

Revue / Journal Title

The American journal of clinical nutrition    ISSN  0002-9165   CODEN AJCNAC 

Source / Source

Congrès
Nutrition and Brain Aging: Normal and Pathologic. Workshop, Paris , FRANCE (19/11/1997)
2000, vol. 71, no 2, pp. 607S-655S (30 ref.), pp. 507-513

Langue / Language

Anglais

Editeur / Publisher

American Society for Nutrition, Bethesda, MD, ETATS-UNIS  (1954) (Revue)

Mots-clés anglais / English Keywords

Retinol

;

Supplemented diet

;

Breast feeding

;

Growth

;

Anthropometry

;

Sex

;

Age

;

Vitamin deficiency

;

Vitamin

;

Randomized design

;

Indonesia

;

Infant

;

Child

;

Preschool age

;

Asia

;

Feeding

;

Corporal biometry

;

Nutrition disorder

;

Human

;

Mots-clés français / French Keywords

Rétinol

;

Régime alimentaire enrichi

;

Allaitement

;

Croissance

;

Anthropométrie

;

Sexe

;

Age

;

Carence vitaminique

;

Vitamine

;

Plan randomisé

;

Indonésie

;

Nourrisson

;

Enfant

;

Age préscolaire

;

Asie

;

Alimentation

;

Biométrie corporelle

;

Trouble nutrition

;

Homme

;

Mots-clés espagnols / Spanish Keywords

Retinol

;

Régimen alimenticio enriquecido

;

Lactancia

;

Crecimiento

;

Antropometría

;

Sexo

;

Edad

;

Carencia vitamínica

;

Vitamina

;

Plan aleatorizado

;

Indonesia

;

Lactante

;

Niño

;

Edad preescolar

;

Asia

;

Alimentación

;

Biometría corporal

;

Trastorno nutricíon

;

Hombre

;

Localisation / Location

INIST-CNRS, Cote INIST : 8263, 35400008161763.0160

Nº notice refdoc (ud4) : 1260648



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