Titre du document / Document title
Antinociceptive properties of the methanolic extract obtained from Ipomoea pes-caprae (L.) R. Br.
Auteur(s) / Author(s)
DE SOUZA M. M. (1) ;
MADEIRA A. (1) ;
BERTI C. (1) ;
KROGH R. (2) ;
YUNES R. A. (2) ;
CECHINEL-FILHO V. (1) ;
Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
(1) Núcleo de Investigações Químico-Farmacêuticas (NIQFAR)/CCS, Universidade do Vale do Itajaí (UNIVALI), 88302-202, Itajai SC, BRESIL
(2) Departamento de Química, Universidade Federal de Santa Catarina (UFSC), 88049900, Florianópolis, SC, BRESIL
Résumé / Abstract
Ipomoea pes-caprae is a medicinal plant used in many countries for the treatment of several ailments, including inflammatory and algesic processes. The present study describes the antinociceptive effects of the methanolic extract and two fractions obtained from aerial parts of this plant. The results indicated that both methanolic extract and two fractions (ethyl acetate and aqueous) exhibited considerable antinociceptive activity against two classical models of pain in mice. Methanolic extract presented a calculated ID
50 value of 33.8 mg/kg, i.p. against writhing test and also inhibited both phases of pain (neurogenic and inflammatory) of the formalin test with ID
50 of 37.7 and 12.5 mg/kg, i.p. for the first and second phase, respectively. Preliminary phytochemical analysis suggested the presence of steroids, terpenoids, alkaloids and flavonoids. These findings support, at least in part, the popular use of I. pes-caprae to treat dolorous processes.
Revue / Journal Title
Journal of ethnopharmacology
ISSN
0378-8741
CODEN JOETD7
Source / Source
2000, vol. 69, n
o1, pp. 85-90 (17 ref.)
Langue / Language
Anglais
Editeur / Publisher
Elsevier, Shanno, IRLANDE
(1978)
(Revue)
Mots-clés anglais / English Keywords
Plant origin ;
Extract ;
Above ground plant part ;
Phytotherapy ;
Treatment ;
Intraperitoneal administration ;
Pain ;
Inflammation ;
Analgesic ;
Medicinal plant ;
Pharmacognosy ;
Folk medicine ;
Brazil ;
Ipomoea ;
Convolvulaceae ;
Dicotyledones ;
Angiospermae ;
Spermatophyta ;
South America ;
America ;
Mots-clés français / French Keywords
Origine végétale ;
Extrait ;
Partie aérienne végétal ;
Phytothérapie ;
Traitement ;
Voie intrapéritonéale ;
Douleur ;
Inflammation ;
Analgésique ;
Plante médicinale ;
Pharmacognosie ;
Médecine traditionnelle ;
Brésil ;
Ipomoea pes-caprae ;
Ipomoea ;
Convolvulaceae ;
Dicotyledones ;
Angiospermae ;
Spermatophyta ;
Amérique du Sud ;
Amérique ;
Mots-clés espagnols / Spanish Keywords
Origen vegetal ;
Extracto ;
Parte aérea vegetal ;
Fitoterapia ;
Tratamiento ;
Vía intraperitoneal ;
Dolor ;
Inflamación ;
Analgésico ;
Planta medicinal ;
Farmacognosia ;
Medicina tradicional ;
Brasil ;
Ipomoea ;
Convolvulaceae ;
Dicotyledones ;
Angiospermae ;
Spermatophyta ;
America del sur ;
America ;
Localisation / Location
INIST-CNRS, Cote INIST : 18028, 35400008146764.0120
Nº notice refdoc (ud4) : 1249377
