Titre du document / Document title

Coexistence of factor V Leiden and factor II A20210 mutations and recurrent venous thromboembolism

Auteur(s) / Author(s)

MARGAGLIONE M. ; D'ANDREA G. ; COLAIZZO D. ; CAPPUCCI G. ; DEL POPOLO A. ; BRANCACCIO V. ; CIAMPA A. ; GRANDONE E. ; DI MINNO G. ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

Unita'di Aterosclerosi e Trombosi, I.R.C.C.S. Casa Sollievo della Sofferenza, S. Giovanni Rotondo, ITALIE
Divisione di Ematologia, Unità di Coagulazione, Ospedale A. Cardarelli, Napoli, ITALIE
Divisione di Ematologia, Ospedale G. Moscati, Avellino, ITALIE
Istituto di Medicina Interna e Geriatria, Università di Palermo, ITALIE

Résumé / Abstract

Patients carrying the FV Leiden or the FII A²⁰²¹⁰ mutation have a high risk of venous thromboembolism. Among 542 patients with a documented diagnosis of deep venous thrombosis in one leg consecutively referred for a thrombophilic work-up, we have retrospectively assessed the rate of objectively documented previous recurrence in carriers of both FV Leiden and FII A²⁰²¹⁰ mutations. Eighty-two patients had experienced 115 episodes of recurrent venous thromboembolism. The rate of recurrent venous thromboembolism was 29.2% among subjects with and 14.5% in those without deficiencies of natural anticoagulant proteins (p = 0.055), and 24.6% among patients with and 14.0% in those without antiphospholipid antibodies (p = 0.036). The frequency of having a recurrent thromboembolism was 16.2%, 20.0%, and 36.4% among carriers of FV Leiden, FII A²⁰²¹⁰ mutation, or both gene defects, respectively, and 12.8% in subjects carrying neither mutation (p for trend = 0.004). When adjusted for age, sex, and thrombophilic risk factors, the rate was higher among patients with than in those without deficiencies of natural anticoagulant proteins (OR: 3.0; 95% Cl: 1.2-7.5), aPL 2.5 (95% Cl: 1.3-4.9), or both FV Leiden and FII A²⁰²¹⁰ gene mutations (OR 4.8; 95% Cl: 1.9-12.2). The rate of previous recurrent venous thromboembolism was significantly higher in subjects carrying both FV Leiden and FII 20210 mutations and was comparable to that observed in subjects with deficiencies of natural anticoagulant proteins or antiphospholipid antibodies.

Revue / Journal Title

Thrombosis and haemostasis   ISSN 0340-6245   CODEN THHADQ 

Source / Source

1999, vol. 82, n^o6, pp. 1583-1587 (33 ref.)

Langue / Language

Anglais

Editeur / Publisher

Schattauer, Stuttgart, ALLEMAGNE  (1976) (Revue)

Mots-clés anglais / English Keywords

Thrombosis ; Vein ; Thromboembolism ; Recurrent ; Factor V Leiden ; Gene ; Resistance ; Protein C (activated) ; Prothrombin ; Coagulation factor ; Mutation ; Risk factor ; Human ; Serine endopeptidases ; Peptidases ; Hydrolases ; Enzyme ; Cardiovascular disease ; Vascular disease ; Venous disease ; Genetics ; Hemopathy ; Coagulopathy ; Genetic disease ;

Mots-clés français / French Keywords

Thrombose ; Veine ; Thromboembolie ; Récidivant ; Facteur V Leiden ; Gène ; Résistance ; Protein C (activated) ; Prothrombine ; Facteur coagulation ; Mutation ; Facteur risque ; Homme ; Serine endopeptidases ; Peptidases ; Hydrolases ; Enzyme ; Appareil circulatoire pathologie ; Vaisseau sanguin pathologie ; Veine pathologie ; Génétique ; Hémopathie ; Coagulopathie ; Maladie héréditaire ;

Mots-clés espagnols / Spanish Keywords

Trombosis ; Vena ; Tromboembolia ; Recidivante ; Factor V Leiden ; Gen ; Resistencia ; Protein C (activated) ; Protrombina ; Factor coagulación ; Mutación ; Factor riesgo ; Hombre ; Serine endopeptidases ; Peptidases ; Hydrolases ; Enzima ; Aparato circulatorio patología ; Vaso sanguíneo patología ; Vena patología ; Genética ; Hemopatía ; Coagulopatía ; Enfermedad hereditaria ;

Localisation / Location

INIST-CNRS, Cote INIST : 10255, 35400008023328.0050