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Titre du document / Document title

β-casomorphin induces Fos-like immunoreactivity in discrete brain regions relevant to schizophrenia and autism

Auteur(s) / Author(s)

ZHONGJIE SUN (1) ; CADE J. R. (1) ; FREGLY M. J. (1) ; PRIVETTE R. M. (1) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) University of Florida, ETATS-UNIS

Résumé / Abstract

ABSTRAC T The induction of Fos-like immunoreactivity (FLI) was used to determine the brain localization affected by β-casomorphin-7 (β-CM7). Peripheral administration of human β-CM7 at different doses (5, 10 and 30 μg/kg, IV for 1 hour) to rats induced moderate to strong FLI in discrete brain regions including the nudeus accumbens, caudate putamen, ventral tegmental and median raphe nucleus, and orbitofrontal, prefrontal, parietal, temporal, occipital and entorhinal cortex. All of the above areas have been shown to be altered either functionally or anatomically in patients with schizophrenia, and most have been shown to be functionally abnormal in autism. Some of these brain areas are originators or components of dopaminergic, serotoninergic and GABA-ergic pathways, suggesting that β-CM7 can affect the function of all of these systems. The role of some other affected areas in emotional and motivated behavior, social adaptation, hallucinations and delusions suggests that β-CM7, which was found in high concentration in the CSF, blood and urine of patients with either schizophrenia or autism, may be relevant to schizophrenia and autism. Induction of FLI in the above brain areas by a moderate dose (10 μg/kg) of β-CM7 was attenuated significantly, or blocked, by pretreatment with naloxone (2 mg/kg, IP). It is concluded that human β-CM7 can cross the blood-brain barrier, activate opioid receptors and affect brain regions similar to those affected by schizophrenia and autism.

Revue / Journal Title

Autism    ISSN  1362-3613 

Source / Source

1999, vol. 3, no1, pp. 67-83 (3 p.1/2)

Langue / Language

Anglais

Editeur / Publisher

Sage Publications, London, ROYAUME-UNI  (1997) (Revue)

Mots-clés anglais / English Keywords

Autism

;

Schizophrenia

;

Casomorphin

;

Localization

;

Brain (vertebrata)

;

Topography

;

Immunohistochemistry

;

Animal

;

Rat

;

Rodentia

;

Mammalia

;

Vertebrata

;

Developmental disorder

;

Psychosis

;

Mots-clés français / French Keywords

Autisme

;

Schizophrénie

;

Casomorphine

;

Localisation

;

Encéphale

;

Topographie

;

Immunohistochimie

;

Animal

;

Rat

;

Gène fos

;

Rodentia

;

Mammalia

;

Vertebrata

;

Trouble développement

;

Psychose

;

Mots-clés espagnols / Spanish Keywords

Autismo

;

Esquizofrenia

;

Localización

;

Encéfalo

;

Topografía

;

Inmunohistoquímica

;

Animal

;

Rata

;

Rodentia

;

Mammalia

;

Vertebrata

;

Trastorno desarrollo

;

Psicosis

;

Localisation / Location

INIST-CNRS, Cote INIST : 26739, 35400008024359.0050

Nº notice refdoc (ud4) : 1191538



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