Titre du document / Document title
Neuroprotective role of curcumin from Curcuma longa on ethanol-induced brain damage
Auteur(s) / Author(s)
RAJAKRISHNAN V. ;
VISWANATHAN P. ;
RAJASEKHARAN K. N. ;
MENON V. P. ;
Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
Department of Biochemistry, Annamalai University, Annamalai Nagar-608 002, INDE
Department of Pathology, RMMC, Annamalai University, Annamalai Nagar-608 002, INDE
Department of Chemistry, University of Kerala, Kariavattom Campus, Trivandrum-695 581, INDE
Résumé / Abstract
In the present study, curcumin from Curcuma longa was screened for neuroprotective activity using ethanol as a model of brain injury. Oral administration of curcumin to rats caused a significant reversal in lipid peroxidation, brain lipids and produced enhancement of glutathione, a non-enzymic antioxidant in ethanol intoxicated rats, revealing that the antioxidative and hypolipidaemic action of curcumin is responsible for its protective role against ethanol induced brain injury.
Revue / Journal Title
PTR. Phytotherapy research
ISSN 0951-418X
Source / Source
1999, vol. 13, n
o7, pp. 571-574 (31 ref.)
Langue / Language
Anglais
Editeur / Publisher
Wiley, Chichester, ROYAUME-UNI
(1987)
(Revue)
Mots-clés anglais / English Keywords
Curcumin ;
Neuroprotective agent ;
Oral administration ;
Phytotherapy ;
Treatment ;
Cerebral disorder ;
Mouse ;
Animal ;
Antioxidant ;
India ;
Curcuma ;
Zingiberaceae ;
Monocotyledones ;
Angiospermae ;
Spermatophyta ;
Rodentia ;
Mammalia ;
Vertebrata ;
Asia ;
Nervous system diseases ;
Central nervous system disease ;
Mots-clés français / French Keywords
Curcumine ;
Neuroprotecteur ;
Voie orale ;
Phytothérapie ;
Traitement ;
Encéphale pathologie ;
Souris ;
Animal ;
Antioxydant ;
Inde ;
Curcuma longa ;
Curcuma ;
Zingiberaceae ;
Monocotyledones ;
Angiospermae ;
Spermatophyta ;
Rodentia ;
Mammalia ;
Vertebrata ;
Asie ;
Système nerveux pathologie ;
Système nerveux central pathologie ;
Mots-clés espagnols / Spanish Keywords
Curcumina ;
Neuroprotector ;
Vía oral ;
Fitoterapia ;
Tratamiento ;
Encéfalo patología ;
Ratón ;
Animal ;
Antioxidante ;
India ;
Curcuma ;
Zingiberaceae ;
Monocotyledones ;
Angiospermae ;
Spermatophyta ;
Rodentia ;
Mammalia ;
Vertebrata ;
Asia ;
Sistema nervioso patología ;
Sistema nervosio central patología ;
Localisation / Location
INIST-CNRS, Cote INIST : 21695, 35400008835341.0050
Nº notice refdoc (ud4) : 1183473
