Titre du document / Document title
Changes in renal function during weight loss induced by high vs low-protein low-fat diets in overweight subjects
Auteur(s) / Author(s)
SKOV A. R.
(1) ;
TOUBRO S.
(1) ;
BÜLOW J.
(2) ;
KRABBE K.
(3) ;
PARVING H.-H.
(4) ;
ASTRUP A.
(1) ;
Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
(1) Research Department of Human Nutrition, The Royal Veterinary and Agricultural University, Copenhagen, DANEMARK
(2) Department of Clinical Physiology, Bispebjerg Hospital, Copenhagen, DANEMARK
(3) Danish Research Centre of Magnetic Resonance, Hvidovre University Hospital, DANEMARK
(4) Steno Diabetes Center, Gentofte, DANEMARK
Résumé / Abstract
BACKGROUND: Due to the high satiating effect of protein, a high-protein diet may be desirable in the treatment of obesity. However the long-term effect of different levels of protein intake on renal function is unclear. OBJECTIVE: To assess the renal effects of high vs low protein contents in fat-reduced diets. DESIGN: Randomized 6 months dietary intervention study comparing two controlled ad libitum diets with 30 energy (E%) fat content: high-protein (HP; 25 E%) or low-protein, (LP, 12 E% protein). All food was provided by self-selection in a shop at the department, and high compliance to the diet composition was confirmed by measurements of urinary nitrogen excretion. SUBJECTS: 65 healthy, overweight and obese (25 <body mass index (BMI) <34 kg/m
2). RESULTS: Dietary protein intake changed from 91.1 g/d to a 6 months intervention average of 70.4 g/d (P <0.05) in the LP group and from 91.4 g/d to 107.8 g/d (P <0.05) in the HP group, producing changes in glomular filtration rate (GFR) of -7.1 ml/min in the LP group and + 5.2 ml/min in the HP group (group effect: P <0.05). Kidney volume decreased by - 6.2 cm
3 in the LP group and increased by +9.1 cm
3 in the HP group (P <0.05), whereas albuminuria remained unchanged in all groups. CONCLUSION: Moderate changes in dietary protein intake cause adaptive alterations in renal size and function without indications of adverse effects.
Revue / Journal Title
International journal of obesity
ISSN 0307-0565
CODEN IJOBDP
Source / Source
1999, vol. 23, n
o11, pp. 1170-1177 (34 ref.)
Langue / Language
Anglais
Editeur / Publisher
Nature Publishing, Basingstoke, ROYAUME-UNI
(1977)
(Revue)
Mots-clés anglais / English Keywords
Overweight ;
Weight loss ;
Renal function ;
Obesity ;
Glomerular filtration ;
Deficient diet ;
Protein ;
Fat ;
Lipids ;
Biological effect ;
Human ;
Nutritional status ;
Nutrition disorder ;
Mots-clés français / French Keywords
Surcharge pondérale ;
Perte poids ;
Fonction rénale ;
Obésité ;
Filtration glomérulaire ;
Régime alimentaire dépourvu ;
Protéine ;
Matière grasse ;
Lipide ;
Effet biologique ;
Homme ;
Etat nutritionnel ;
Trouble nutrition ;
Mots-clés espagnols / Spanish Keywords
Sobrecarga ponderal ;
Adelgazamiento ;
Función renal ;
Obesidad ;
Filtración glomerular ;
Régimen alimenticio deficiente ;
Proteína ;
Materia grasa ;
Lípido ;
Efecto biológico ;
Hombre ;
Estado nutricional ;
Trastorno nutricíon ;
Localisation / Location
INIST-CNRS, Cote INIST : 18243, 35400008075542.0090
Nº notice refdoc (ud4) : 1181460
