Titre du document / Document title

High estradiol levels and high oocyte yield are not detrimental to in vitro fertilization outcome

Auteur(s) / Author(s)

SHARARA F. I. ⁽¹⁾ ; MCCLAMROCK H. D. ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Division of Reproductive Endocrinology and Infertility, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Maryland School of Medicine, Baltimore, Maryland, ETATS-UNIS

Résumé / Abstract

Objective: To evaluate the impact of elevated peak E₂ levels and a high number of retrieved oocytes on implantation in patients undergoing assisted reproductive techniques. Design: Retrospective study. Setting: University-based IVF program. Patient(s): One hundred six patients undergoing 106 IVF cycles. High responders were defined as those who had peak E₂ levels of >3,000 pg/mL on the day of hCG administration (n = 38) or > 15 retrieved oocytes (n = 48). Their IVF outcomes were compared with those of patients whose peak E₂ levels were ≤3,000 pg/mL (n = 68) or who had ≤15 retrieved oocytes (n = 58). Intervention(s): None. Main Outcome Measure(s): Implantation and pregnancy rates. Result(s): There were no statistically significant differences in age, basal FSH level, basal E₂ level, number of ampules of gonadotropins required, fertilization rate, number of ETs, implantation rate, or pregnancy rate between normal and high responders or between women who did and did not become pregnant. In addition, no differences were detected when outcome was analyzed according to the stimulation regimen used. Conclusion(s): Elevated peak E₂ levels and high oocyte yield are not detrimental to IVF outcome. More studies are needed to characterize the threshold E₂ levels above which implantation rates are reduced.

Revue / Journal Title

Fertility and sterility   ISSN 0015-0282   CODEN FESTAS 

Source / Source

1999, vol. 72, n^o3, pp. 401-405 (18 ref.)

Langue / Language

Anglais

Editeur / Publisher

Elsevier Science, New York, NY, ETATS-UNIS  (1950) (Revue)

Mots-clés anglais / English Keywords

In vitro fertilization embryo transfer ; Estradiol ; Oocyte ; Ovum implantation ; Follicle stimulating hormone ; Pregnancy ; Woman ; Assisted procreation ; Estrogen ; Ovarian hormone ; Sex steroid hormone ; Germinal cell ; Gonadotropin ; Adenohypophyseal hormone ; Human ;

Mots-clés français / French Keywords

Fécondation in vitro transfert embryon ; Estradiol ; Ovocyte ; Implantation oeuf ; FSH ; Gestation ; Femme ; Procréation assistée ; Oestrogène ; Hormone ovarienne ; Hormone stéroïde sexuelle ; Cellule germinale ; Gonadotrophine ; Hormone adénohypophysaire ; Homme ;

Mots-clés espagnols / Spanish Keywords

Fecundación in vitro transplante embrión ; Estradiol ; Ovocito ; Implantation huevo ; FSH ; Gestación ; Mujer ; Procreación asistida ; Estrógeno ; Hormona ovárica ; Hormona esteroide sexual ; Célula germinal ; Gonadotropina ; Hormona adenohipofisaria ; Hombre ;

Localisation / Location

INIST-CNRS, Cote INIST : 4120, 35400008997323.0030