Titre du document / Document title
Isolation and identification of the toxic peptides from Lophyrotoma zonalis (Pergidae) sawfly larvae
Auteur(s) / Author(s)
OELRICHS P. B. (1) ;
MACLEOD J. K. (2) ;
SEAWRIGHT A. A. (1) ;
GRACE P. B. (2) ;
Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
(1) National Research Centre for Environmental Toxicology, 39 Kessels Road, Coopers Plains, Qld 4108, AUSTRALIE
(2) Research School of Chemistry, Australian National University, Canberra, ACT 0200, AUSTRALIE
Résumé / Abstract
The broad-leaved paper bark tree Melaleuca quinquenervia (Cav) (Myrtaceae) was introduced into Florida (USA) early in this century it has proliferated to such an extent that urgent measures are now required to control it. The sawfly Lophyrotoma zonalis (Pergidae) has been introduced as a possible biological control agent due to its ability to defoliate M. quinquenervia. Because toxic D-amino acid- containing peptides have been isolated from some sawfly species, L. zonalis larvae were processed using the previously reported method for the recovery of these compounds. The toxins lophyrotomin (as the free C-terminal acid) and a mixture of pergidin and Val
4-pergidin were isolated at 0.36 and 0.43% yield of the dried larvae, respectively. Both compounds when dosed intraperitoneally to C57/B16 male mice were hepatotoxic with lowest lethal doses of 8 and 32 mg/kg, respectively. The pathology of the liver was different for each compound, with the lophyrotomin free acid causing a periportal haemorrhagic necrosis and the pergidin causing a periacinar coagulative necrosis.
Revue / Journal Title
Toxicon
ISSN
0041-0101
CODEN TOXIA6
Source / Source
2001, vol. 39, n
o12, pp. 1933-1936 (8 ref.)
Langue / Language
Anglais
Editeur / Publisher
Elsevier, Kidlington, ROYAUME-UNI
(1962)
(Revue)
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Localisation / Location
INIST-CNRS, Cote INIST : 10409, 35400009961823.0170
Nº notice refdoc (ud4) : 1138621
