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Titre du document / Document title

Anti-tumor promoting activity of bufadienolides from Kalanchoe pinnata and K. daigremontiana x tubiflora

Auteur(s) / Author(s)

SUPRATMAN Unang (1) ; FUJITA Tomoyuki (1) ; AKIYAMA Kohki (1) ; HAYASHI Hideo (1) ; MURAKAMI Akira (2) ; SAKAI Hirofumi (2) ; KOSHIMIZU Koichi (2) ; OHIGASHI Hajime (3) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Division of Applied Biological Chemistry, Graduate School of Agriculture and Life Sciences, Osaka Prefecture University, 1-1 Gakuen-cho, Sakai, Osaka 599-8531, JAPON
(2) Department of Biotechnological Science, Faculty of Biology-oriented Science and Technology, Kinki University, Iwade-Uchita, Wakayama 649-6493, JAPON
(3) Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, JAPON

Résumé / Abstract

Five bufadienolides (1-5) isolated from the leaves of Kalanchoe pinnata and K. daigremontiana x tubiflora (Crassulaceae) were examined for their inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation in Raji cells induced by the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate. All bufadienolides showed inhibitory activity, and bryophyllin A (1) exhibited the most marked inhibition (IC50=0.4 μM) among the tested compounds. Bryophyllin C (2), a reduction analogue of 1, and bersaldegenin-3-acetate (3) lacking the orthoacetate moiety were less active. These results strongly suggest that bufadienolides are potential cancer chemopreventive agents.

Revue / Journal Title

Bioscience, biotechnology, and biochemistry    ISSN  0916-8451 

Source / Source

2001, vol. 65, no4, pp. 947-949 (14 ref.)

Langue / Language

Anglais

Editeur / Publisher

Japan Society for Bioscience Biotechnology and Agrochemistry, Tokyo, JAPON  (1992) (Revue)

Mots-clés anglais / English Keywords

Bufadienolide

;

Plant origin

;

Medicinal plant

;

Plant leaf

;

Biological activity

;

Antitumor promotor

;

Prevention

;

Epstein Barr virus

;

In vitro

;

Pharmacognosy

;

Tumor cell

;

Cell line

;

Crassulaceae

;

Dicotyledones

;

Angiospermae

;

Spermatophyta

;

Gammaherpesvirinae

;

Herpesviridae

;

Virus

;

Mots-clés français / French Keywords

Bufadiénolide

;

Origine végétale

;

Plante médicinale

;

Feuille végétal

;

Activité biologique

;

Antipromoteur tumeur

;

Prévention

;

Virus Epstein Barr

;

In vitro

;

Pharmacognosie

;

Cellule tumorale

;

Lignée cellulaire

;

Kalanchoe pinnata

;

kalanchoe daigremontiana

;

Lignée RAJI

;

Crassulaceae

;

Dicotyledones

;

Angiospermae

;

Spermatophyta

;

Gammaherpesvirinae

;

Herpesviridae

;

Virus

;

Mots-clés espagnols / Spanish Keywords

Bufadienólido

;

Origen vegetal

;

Planta medicinal

;

Hoja vegetal

;

Actividad biológica

;

Antitumoral promotor

;

Prevención

;

Epstein Barr virus

;

In vitro

;

Farmacognosia

;

Célula tumoral

;

Línea celular

;

Crassulaceae

;

Dicotyledones

;

Angiospermae

;

Spermatophyta

;

Gammaherpesvirinae

;

Herpesviridae

;

Virus

;

Localisation / Location

INIST-CNRS, Cote INIST : 8935, 35400009649246.0310

Nº notice refdoc (ud4) : 1116736



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