Titre du document / Document title
Anti-tumor promoting activity of bufadienolides from Kalanchoe pinnata and K. daigremontiana x tubiflora
Auteur(s) / Author(s)
SUPRATMAN Unang (1) ;
FUJITA Tomoyuki (1) ;
AKIYAMA Kohki (1) ;
HAYASHI Hideo (1) ;
MURAKAMI Akira (2) ;
SAKAI Hirofumi (2) ;
KOSHIMIZU Koichi (2) ;
OHIGASHI Hajime (3) ;
Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
(1) Division of Applied Biological Chemistry, Graduate School of Agriculture and Life Sciences, Osaka Prefecture University, 1-1 Gakuen-cho, Sakai, Osaka 599-8531, JAPON
(2) Department of Biotechnological Science, Faculty of Biology-oriented Science and Technology, Kinki University, Iwade-Uchita, Wakayama 649-6493, JAPON
(3) Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, JAPON
Résumé / Abstract
Five bufadienolides (1-5) isolated from the leaves of Kalanchoe pinnata and K. daigremontiana x tubiflora (Crassulaceae) were examined for their inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation in Raji cells induced by the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate. All bufadienolides showed inhibitory activity, and bryophyllin A (1) exhibited the most marked inhibition (IC
50=0.4 μM) among the tested compounds. Bryophyllin C (2), a reduction analogue of 1, and bersaldegenin-3-acetate (3) lacking the orthoacetate moiety were less active. These results strongly suggest that bufadienolides are potential cancer chemopreventive agents.
Revue / Journal Title
Bioscience, biotechnology, and biochemistry
ISSN
0916-8451
Source / Source
2001, vol. 65, n
o4, pp. 947-949 (14 ref.)
Langue / Language
Anglais
Editeur / Publisher
Japan Society for Bioscience Biotechnology and Agrochemistry, Tokyo, JAPON
(1992)
(Revue)
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Localisation / Location
INIST-CNRS, Cote INIST : 8935, 35400009649246.0310
Nº notice refdoc (ud4) : 1116736
