RefDoc
Haut

Faire une nouvelle recherche
Make a new search
Lancer la recherche


Titre du document / Document title

Effect of sleep deprivation on motor performance in patients with Parkinson's Disease

Auteur(s) / Author(s)

HÖGL Birgit (1) ; PERALTA Cecilia (2) ; WETTER Thomas C. (1) ; GERSHANIK Oscar (2) ; TRENKWALDER Claudia (1) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Max Planck Institute of Psychiatry, Neurology Department, Munich, ALLEMAGNE
(2) Extrapyramidal Diseases Section, Centro Neurológico, Hospital Francés, Buenos Aires, ARGENTINE

Résumé / Abstract

Animal research provides evidence that sleep deprivation influences the dopamine system. Knowledge about the effect of sleep deprivation on motor performance in patients with Parkinsons disease is scarce. This study examines the influence of total and partial sleep deprivation compared to normal sleep on motor state and performance in Parkinson's disease. Fifteen nondepressed patients with Parkinson's disease underwent one night of total sleep deprivation (TSD), one night of partial sleep deprivation (PSD) after 3 a.m., and one control night of normal sleep (S), performed in a random, nonconsecutive order. Over a period of 3 hours the following morning, motor evaluations (United Parkinson's Disease Rating Scale. [UPDRS] and tapping rate) were performed before and every 30 minutes after intake of the usual morning dopaminergic drug dose. All patients underwent polysomnography apart from the sleep deprivation protocol. Mean UPDRS motor scores and tapping velocities did not differ significantly after each of the schedules, but a subgroup of four patients improved their motor score after partial sleep deprivation. These data do not confirm previous findings of an overall positive influence of sleep deprivation on motor function in Parkinson's disease. However, the results indicate that different response types to sleep deprivation may exist and that a subgroup of patients could benefit from partial sleep deprivation.

Revue / Journal Title

Movement disorders    ISSN  0885-3185 

Source / Source

2001, vol. 16, no4, pp. 616-621 (33 ref.)

Langue / Language

Anglais

Editeur / Publisher

Wiley, Hoboken, NJ, ETATS-UNIS  (1986) (Revue)

Mots-clés anglais / English Keywords

Parkinson disease

;

Deprivation

;

Sleep

;

Motricity

;

Polygraphy

;

Electrodiagnosis

;

Evolution

;

Human

;

Nervous system diseases

;

Central nervous system disease

;

Cerebral disorder

;

Extrapyramidal syndrome

;

Degenerative disease

;

Mots-clés français / French Keywords

Parkinson maladie

;

Privation

;

Sommeil

;

Motricité

;

Polygraphie

;

Electrodiagnostic

;

Evolution

;

Homme

;

Système nerveux pathologie

;

Système nerveux central pathologie

;

Encéphale pathologie

;

Extrapyramidal syndrome

;

Maladie dégénérative

;

Mots-clés espagnols / Spanish Keywords

Parkinson enfermedad

;

Privación

;

Sueño

;

Motricidad

;

Poligrafía

;

Electrodiagnóstico

;

Evolución

;

Hombre

;

Sistema nervioso patología

;

Sistema nervosio central patología

;

Encéfalo patología

;

Extrapiramidal síndrome

;

Enfermedad degenerativa

;

Localisation / Location

INIST-CNRS, Cote INIST : 20953, 35400009712119.0050

Nº notice refdoc (ud4) : 1101196



Faire une nouvelle recherche
Make a new search
Lancer la recherche
Bas