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Titre du document / Document title

Longovital® and herpes labialis : a randomised, double-blind, placebo-controlled study

Auteur(s) / Author(s)

PEDERSEN A. (1) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) The Oral Medicine Clinic, Peblingesøen, Copenhagen, DANEMARK

Résumé / Abstract

OBJECTIVE: LongoVital (LV) (DK. Reg. No. 5178/75) is a herbal-based tablet enriched with the recommended daily doses of vitamins. The present study was undertaken to investigate possible prevention of recurrent herpes labialis (RHL) during 4 months' daily intake of LV. DESIGN: Placebo-controlled, double-blind, randomised, clinical trial. SUBJECTS: Fifty-two patients with a minimum of 4 yearly HL episodes. METHODS: The patients were given either LV or placebo for 4 months and followed-up for another 4 months. The number, duration and maximal size of lesions were assessed. RESULTS: Twenty-seven patients (Group A) received LV and 25 patients placebo (Group B). There were no statistically significant differences between Group A and Group B with respect to number, duration and size of lesions. Within Group A, however, there was a decrease in all three parameters after 2 months' intake of LV (p < 0.05). The decrease in the number of HL episodes in Group A lasted during the entire follow-up period (p < 0.05). At the end of the medication period, significantly more patients in Group A than in Group B assessed the number and duration of recurrences to be reduced compared with before the trial (p < 0.05). CONCLUSION: LV was not superior to placebo in the prevention of RHL although subjective assessment was in favour of LV, and the LV group had less episodes after 2 months on the tablets.

Revue / Journal Title

Oral diseases    ISSN  1354-523X 

Source / Source

2001, vol. 7, no4, pp. 221-225 (13 ref.)

Langue / Language

Anglais

Editeur / Publisher

Blackwell, Oxford, ROYAUME-UNI  (1995) (Revue)

Mots-clés anglais / English Keywords

Herpes

;

Lip

;

Performance evaluation

;

Treatment efficiency

;

Prevention

;

Vitamin

;

Food supplement

;

Medicinal plant

;

Application method

;

Controlled therapeutic trial

;

Double blind study

;

Randomization

;

Statistical analysis

;

Relapse

;

Symptomatology

;

Human

;

Viral disease

;

Infection

;

ENT disease

;

Mots-clés français / French Keywords

Herpès

;

Lèvre

;

Evaluation performance

;

Efficacité traitement

;

Prévention

;

Vitamine

;

Complément alimentaire

;

Plante médicinale

;

Modalité traitement

;

Essai thérapeutique contrôlé

;

Etude double insu

;

Randomisation

;

Analyse statistique

;

Récidive

;

Symptomatologie

;

Homme

;

Virose

;

Infection

;

ORL pathologie

;

Mots-clés espagnols / Spanish Keywords

Herpes

;

Labio

;

Evaluación prestación

;

Eficacia tratamiento

;

Prevención

;

Vitamina

;

Complemento alimentario

;

Planta medicinal

;

Modalidad tratamiento

;

Ensayo terapéutico controlado

;

Estudio doble ciego

;

Aleatorización

;

Análisis estadístico

;

Recaida

;

Sintomatología

;

Hombre

;

Virosis

;

Infección

;

ORL patología

;

Localisation / Location

INIST-CNRS, Cote INIST : 26715, 35400009668030.0040

Nº notice refdoc (ud4) : 1100816



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