Titre du document / Document title
Longovital® and herpes labialis : a randomised, double-blind, placebo-controlled study
Auteur(s) / Author(s)
PEDERSEN A. (1) ;
Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
(1) The Oral Medicine Clinic, Peblingesøen, Copenhagen, DANEMARK
Résumé / Abstract
OBJECTIVE: LongoVital (LV) (DK. Reg. No. 5178/75) is a herbal-based tablet enriched with the recommended daily doses of vitamins. The present study was undertaken to investigate possible prevention of recurrent herpes labialis (RHL) during 4 months' daily intake of LV. DESIGN: Placebo-controlled, double-blind, randomised, clinical trial. SUBJECTS: Fifty-two patients with a minimum of 4 yearly HL episodes. METHODS: The patients were given either LV or placebo for 4 months and followed-up for another 4 months. The number, duration and maximal size of lesions were assessed. RESULTS: Twenty-seven patients (Group A) received LV and 25 patients placebo (Group B). There were no statistically significant differences between Group A and Group B with respect to number, duration and size of lesions. Within Group A, however, there was a decrease in all three parameters after 2 months' intake of LV (p < 0.05). The decrease in the number of HL episodes in Group A lasted during the entire follow-up period (p < 0.05). At the end of the medication period, significantly more patients in Group A than in Group B assessed the number and duration of recurrences to be reduced compared with before the trial (p < 0.05). CONCLUSION: LV was not superior to placebo in the prevention of RHL although subjective assessment was in favour of LV, and the LV group had less episodes after 2 months on the tablets.
Revue / Journal Title
Oral diseases
ISSN
1354-523X
Source / Source
2001, vol. 7, n
o4, pp. 221-225 (13 ref.)
Langue / Language
Anglais
Editeur / Publisher
Blackwell, Oxford, ROYAUME-UNI
(1995)
(Revue)
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Localisation / Location
INIST-CNRS, Cote INIST : 26715, 35400009668030.0040
Nº notice refdoc (ud4) : 1100816
