Titre du document / Document title

The sentinel lymph node status is an important factor for predicting clinical outcome in patients with stage I or II cutaneous melanoma

Auteur(s) / Author(s)

G. STATIUS MULLER Markwin ⁽¹⁾ ; VAN LEEUWEN Paul A. M. ⁽¹⁾ ; DE LANGE-DE KLERK Elly S. M. ⁽²⁾ ; VAN DIEST Paul J. ⁽³⁾ ; PIJPERS Rik ⁽⁴⁾ ; FERWERDA Charlotte C. ⁽¹⁾ ; VUYLSTEKE Ronald J. C. L. M. ⁽¹⁾ ; MEIJER Sybren ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Department of Surgical Oncology, Vrije Universiteit Medical Centre, Amsterdam, PAYS-BAS
⁽²⁾ Department of Epidemiology and Biostatistics, Vrije Universiteit Medical Centre, Amsterdam, PAYS-BAS
⁽³⁾ Department of Pathology, Vrije Universiteit Medical Centre, Amsterdam, PAYS-BAS
⁽⁴⁾ Department of Nuclear Medicine, Vrije Universiteit Medical Centre, Amsterdam, PAYS-BAS

Résumé / Abstract

BACKGROUND. In a cohort of patients, the authors investigated whether and to what extent the sentinel lymph node (SLN) status contributes to predicting the probability of remaining disease free for at least 3 years. In addition, several traditional prognostic factors were analyzed: Breslow thickness, Clark invasion level, ulceration, lymphatic invasion, location, type of the melanoma, and age and gender of the patient. METHODS. In 263 consecutive patients with proven American Joint Committee on Cancer Stages I and II cutaneous melanoma, the triple technique SLN procedure was used, i.e., preoperative visualization of the lymph channels from the initial site of the melanoma toward the SLN by (dynamic) lymphoscintigraphy, intraoperative visualization of those particular lymph channels and lymph nodes with blue dye, and a gamma probe to measure accumulated radioactivity in radiolabeled lymph nodes. Median follow-up time was 48 months (range, 36-84 months). Multivariate logistic regression analysis was performed to examine the influence of the SLN status and several other prognostic factors on a minimum 3-year disease free survival. RESULTS. In 20% of patients, the SLN proved to be tumor positive. For SLN negative patients, the 5-year disease free survival rate was 91% (± 2.4%), and for SLN positive patients it was 49% (± 9%). Five variables showed a strong and statistically significant independent prognostic association with outcome, i.e., SLN status (P = 0.0007), thickness of primary melanoma (1.01-2.0 mm; P = 0.04), ulceration (P = 0.05), and lymphatic invasion (P = 0.01) of primary melanoma, and age (40-50 years; P = 0.01). CONCLUSIONS. The SLN status-along with Breslow thickness, ulceration, lymphatic invasion, and age-seems to have strong additional value in predicting a minimum 3-year disease free period after the SLN procedure. Patients with a positive SLN have a poorer prognosis than those with a negative SLN.

Revue / Journal Title

Cancer   ISSN 0008-543X   CODEN CANCAR 

Source / Source

2001, vol. 91, n^o12, pp. 2401-2408 (31 ref.)

Langue / Language

Anglais

Editeur / Publisher

Wiley-Liss, New York, NY, ETATS-UNIS  (1948) (Revue)

Mots-clés anglais / English Keywords

Melanoma ; Skin ; Early stage ; Ulceration ; Metastasis ; Lymphatic ; Thickness ; Logistic regression ; Statistical analysis ; Prognosis ; Human ; Sentinel lymph node ; Malignant tumor ; Skin disease ; Lymphatic vessel disease ;

Mots-clés français / French Keywords

Mélanome ; Peau ; Stade précoce ; Ulcération ; Métastase ; Lymphatique ; Epaisseur ; Régression logistique ; Analyse statistique ; Pronostic ; Homme ; Indice Breslow ; Ganglion lymphatique sentinelle ; Tumeur maligne ; Peau pathologie ; Lymphatique pathologie ;

Mots-clés espagnols / Spanish Keywords

Melanoma ; Piel ; Estadio precoz ; Ulceración ; Metástasis ; Linfático ; Espesor ; Regresión logística ; Análisis estadístico ; Pronóstico ; Hombre ; Tumor maligno ; Piel patología ; Linfático patología ;

Localisation / Location

INIST-CNRS, Cote INIST : 2701, 35400009651838.0250