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Titre du document / Document title

Temporal lobe rating scale : application to Alzheimer's disease and frontotemporal dementia

Auteur(s) / Author(s)

GALTON C. J. (1) ; GOMEZ-ANSON B. (2) ; ANTOUN N. (2) ; SCHELTENS P. (3) ; PATTERSON K. (4) ; GRAVES M. (2) ; SAHAKIAN B. J. (5) ; HODGES J. R. (1 4) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) University Neurology Unit, Addenbrookes Hospital, Hills Road, Cambridge, CB2 2QQ, ROYAUME-UNI
(2) Department of Radiology, Addenbrookes Hospital, Hills Road, Cambridge, CB2 2QQ, ROYAUME-UNI
(3) Academisch Ziekenhuis VU, 1007 MB Amsterdam, PAYS-BAS
(4) MRC Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge CB2 2EF, ROYAUME-UNI
(5) Department of Psychiatry, University of Cambridge, Addenbrookes Hospital, Cambridge, CB2 2QQ, ROYAUME-UNI

Résumé / Abstract

Objectives-Temporal lobe atrophy as assessed by MRI can be measured in several ways. Volumetric measurements are quantitative but very time consuming and require extensive training to perform, so are not easily transferable to clinical practice. Visual rating scales, by contrast, are quick and widely applicable. Although medial temporal lobe atrophy is well described in Alzheimer's disease (AD), it is uncertain how early these changes can be detected and whether they discriminate AD from other neurodegenerative diseases, most notably frontotemporal dementia (FTD). The objectives were (1) to develop a widely applicable temporal lobe rating scale, and (2) to characterise and quantify the patterns of temporal lobe atrophy in AD versus temporal and frontal variants of FTD. Methods-The temporal lobe assessments were made using an established hippocampal rating scale extended to incorporate additional temporal regions. This was firstly validated with volumetric analysis and then applied to 30 probable AD, 30 FTD (consisting of 17 temporal variant (semantic dementia) and 13 frontal variant) and 18 control coronal MRI images. Results-Bilateral hippocampal atrophy was found in 50% of the patients with AD. Contrary to expectations, patients with semantic dementia also had hippocampal atrophy, which for the left side exceeded that seen in AD; other regions (temporal pole, parahippocampal gyrus, and lateral temporal lobe), spared in AD, were severely atrophied in this group. The patients with frontal variant FTD occupied an intermediate position and were largely indistinguishable from AD. Conclusions-Hippocampal atrophy is, therefore, not specific for AD. Semantic dementia can be distinguished from AD, by the presence of severe bilateral atrophy of the temporal pole, parahippocampal and lateral regions. These findings have implications for the differential diagnosis of dementias.

Revue / Journal Title

Journal of neurology, neurosurgery and psychiatry    ISSN  0022-3050   CODEN JNNPAU 

Source / Source

2001, vol. 70, no2, pp. 165-173 (41 ref.)

Langue / Language

Anglais

Editeur / Publisher

BMJ Publishing Group, London, ROYAUME-UNI  (1944) (Revue)

Mots-clés anglais / English Keywords

Alzheimer disease

;

Dementia

;

Frontal lobe

;

Temporal lobe

;

Nuclear magnetic resonance imaging

;

Atrophy

;

Measurement scale

;

Comparative study

;

Exploration

;

Human

;

Visual observation

;

Nervous system diseases

;

Central nervous system disease

;

Cerebral disorder

;

Degenerative disease

;

Medical imagery

;

Mots-clés français / French Keywords

Démence Alzheimer

;

Démence

;

Lobe frontal

;

Lobe temporal

;

Imagerie RMN

;

Atrophie

;

Echelle mesure

;

Etude comparative

;

Exploration

;

Homme

;

Observation visuelle

;

Système nerveux pathologie

;

Système nerveux central pathologie

;

Encéphale pathologie

;

Maladie dégénérative

;

Imagerie médicale

;

Mots-clés espagnols / Spanish Keywords

Demencia Alzheimer

;

Demencia

;

Lóbulo frontal

;

Lóbulo temporal

;

Imageria RMN

;

Atrofia

;

Escala medida

;

Estudio comparativo

;

Exploración

;

Hombre

;

Observación visual

;

Sistema nervioso patología

;

Sistema nervosio central patología

;

Encéfalo patología

;

Enfermedad degenerativa

;

Imageneria medical

;

Localisation / Location

INIST-CNRS, Cote INIST : 6015, 35400009581878.0060

Nº notice refdoc (ud4) : 1093492



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