Titre du document / Document title

Valsartan alone or with a diuretic or ACE inhibitor as treatment for African American hypertensives : Relation to salt intake

Auteur(s) / Author(s)

WEIR Matthew R. ⁽¹⁾ ; SMITH David H. G. ⁽²⁾ ; NEUTEL Joel M. ⁽²⁾ ; BEDIGIAN Martin P. ⁽³⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Division of Nephrology, Department of Medicine , University of Maryland School of Medicine, Baltimore, Maryland, ETATS-UNIS
⁽²⁾ Orange County Research Institute, Orange, California, ETATS-UNIS
⁽³⁾ Novartis Pharmaceuticals, East Hanover, New Jersey, ETATS-UNIS

Résumé / Abstract

Previous clinical trials have demonstrated the important influence of ethnicity and dietary salt on the antihypertensive efficacy of drugs that block the renin angiotensin system. Angiotensin II receptor blockers are a new therapeutic entity that have not been widely studied in African American hypertensives, either alone, or in combination with other therapies such as diuretics or angiotensin converting enzyme inhibitors. We performed a pilot, prospective, open label, randomized design clinical trial to evaluate the effects of the angiotensin II receptor blocker valsartan (160 mg once a day) on systolic and diastolic blood pressure in hypertensive African Americans (n = 88) on a low salt (100 mEq Na⁺/day) for 2 weeks and the same diet supplemented by 100 mEq Na⁺ for 4 weeks. After this evaluation, while continuing the Na⁺ supplementation, patients were randomized to valsartan 320 mg/ day (n = 28), or the addition of hydrochlorothiazide (HCTZ) 12.5 mg/day (n = 30), or benazepril 20 mg/day to the valsartan 160 mg/day for an additional 6 weeks. Valsartan (160 mg/day) lowered blood pressure significantly in African American patients on both low salt (-6.4/-4.8 mm Hg: P <.001) and a high salt diet (-4.9/-3.8 mm Hg: P =.01). The high salt diet attenuated the antihypertensive effect slightly (1.6/1.3 mm Hg, P = not significant). When comparing the efficacy of the three randomized therapeutic regimens while on the Na⁺ supplement, the valsartan 160 mg/HCTZ 12.5 mg was the most effective therapy with an incremental reduction in blood pressure of -10.5/-6.9 mm Hg (P <.01), compared to valsartan 160 mg/day alone. Doubling the dose of valsartan to 320 mg incrementally lowered blood pressure by -3.8/-3.3 mm Hg (P = not significant). The least effective approach was adding benazepril 20 mg/day to valsartan 160 mg/day with no incremental reduction in systolic blood pressure and diastolic blood pressure reduction of only 1.7 mm Hg (P = not significant). We conclude that in our open label pilot study, the antihypertensive activity of valsartan is not significantly attenuated by supplemented salt diet in hypertensive African Americans. Moreover, adding a low dose of HCTZ appears to be the most effective strategy in enhancing the antihypertensive activity of this angiotensin II receptor blocker in contrast to either doubling the dose or adding an angiotensin converting enzyme inhibitor.

Revue / Journal Title

American journal of hypertension   ISSN 0895-7061 

Source / Source

2001, vol. 14 (1), n^o7, pp. 665-671 (24 ref.)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, New York, NY, ETATS-UNIS  (1988) (Revue)

Mots-clés anglais / English Keywords

Hypertension ; Valsartan ; Angiotensin antagonist ; Diuretic ; Peptidyl-dipeptidase A ; Enzyme inhibitor ; Sodium ; Arterial pressure ; Chemotherapy ; Treatment ; Drug combination ; Human ; Race ; Negroid ; Follow up study ; Antihypertensive agent ; Peptidyl-dipeptidases ; Peptidases ; Hydrolases ; Enzyme ; Cardiovascular disease ;

Mots-clés français / French Keywords

Hypertension artérielle ; Valsartan ; Antagoniste angiotensine ; Diurétique ; Peptidyl-dipeptidase A ; Inhibiteur enzyme ; Sodium ; Pression artérielle ; Chimiothérapie ; Traitement ; Association médicamenteuse ; Homme ; Race ; Négroïde ; Etude longitudinale ; Antihypertenseur ; Angiotensin converting enzyme ; Peptidyl-dipeptidases ; Peptidases ; Hydrolases ; Enzyme ; Appareil circulatoire pathologie ;

Mots-clés espagnols / Spanish Keywords

Hipertensión arterial ; Valsartán ; Antagonista angiotensina ; Diurético ; Peptidyl-dipeptidase A ; Inhibidor enzima ; Sodio ; Presión arterial ; Quimioterapia ; Tratamiento ; Asociación medicamentosa ; Hombre ; Raza ; Negroide ; Estudio longitudinal ; Antihipertensivo ; Peptidyl-dipeptidases ; Peptidases ; Hydrolases ; Enzima ; Aparato circulatorio patología ;

Localisation / Location

INIST-CNRS, Cote INIST : 21579, 35400009662314.0120