Titre du document / Document title
Effects of non-ionic surfactants as permeation enhancers towards piroxicam from the poloxamer gel through rat skins
Auteur(s) / Author(s)
SHIN Sang-Chul
(1) ;
CHO Cheong-Weon
(1) ;
OH In-Joon
(1) ;
Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
(1) College of Pharmacy, Chonnam National University, Kwangju 500-757, COREE, REPUBLIQUE DE
Résumé / Abstract
The enhancing effects of non-ionic surfactants on the permeation of piroxicam from the poloxamer gels were evaluated using Franz diffusion cells fitted with excised rat skins. The effectiveness of penetration enhancers, the ratio of piroxicam flux in the presence or absence of enhancers, was defined as the enhancement factor. Among the various non-ionic surfactants tested, polyoxyethylene-2-oleyl ether showed the highest enhancing effects with an enhancement factor of 2.84. To elucidate the mechanisms of the action of enhancers, thermal analysis and histological examinations were carried out. Thermal analysis reveals that various surfactants have different fluidizing effects on stratum corneum. Skin pretreated with the poloxamer 407 gels containing various surfactants showed a loosely layered stratum corneum and wide intercellular space.
Revue / Journal Title
International journal of pharmaceutics
ISSN 0378-5173
CODEN IJPHDE
Source / Source
2001, vol. 222, n
o2, pp. 199-203 (11 ref.)
Langue / Language
Anglais
Editeur / Publisher
Elsevier, Amsterdam, PAYS-BAS
(1978)
(Revue)
Mots-clés anglais / English Keywords
Pharmaceutical technology ;
Dosage form ;
Piroxicam ;
Drug carrier ;
Control release polymer ;
Poloxamer ;
Absorption enhancer ;
Non ionic surfactant ;
Colloidal gel ;
Animal ;
Rat ;
In vitro ;
Skin ;
Stratum corneum ;
Mechanism of action ;
Permeation ;
Oxicam derivatives ;
Percutaneous route ;
Rodentia ;
Mammalia ;
Vertebrata ;
Mots-clés français / French Keywords
Technologie pharmaceutique ;
Forme pharmaceutique ;
Piroxicam ;
Vecteur médicament ;
Polymère vecteur ;
Poloxamère ;
Promoteur absorption ;
Agent surface non ionique ;
Gel colloïdal ;
Animal ;
Rat ;
In vitro ;
Peau ;
Couche cornée ;
Mécanisme action ;
Perméation ;
Oxicam dérivé ;
Voie percutanée ;
Rodentia ;
Mammalia ;
Vertebrata ;
Mots-clés espagnols / Spanish Keywords
Tecnología farmacéutica ;
Forma farmacéutica ;
Piroxicam ;
Vector medicamento ;
Polímero vector ;
Poloxámero ;
Promotor absorción ;
Agente superficie no iónica ;
Gel coloidal ;
Animal ;
Rata ;
In vitro ;
Piel ;
Estrato córneo ;
Mecanismo acción ;
Permeación ;
Oxicam derivado ;
Vía percutánea ;
Rodentia ;
Mammalia ;
Vertebrata ;
Localisation / Location
INIST-CNRS, Cote INIST : 16510, 35400009843559.0040
Nº notice refdoc (ud4) : 1069241
