Titre du document / Document title

Efficacy of Echinacea purpurea in patients with a common cold: A placebo-controlled, randomised, double-blind clinical trial

Auteur(s) / Author(s)

SCHULTEN Brigitte ⁽¹⁾ ; BULITTA Michael ⁽²⁾ ; BALLERING-BRÜHL Brigitta ⁽³⁾ ; KÖSTER Ulrike ⁽³⁾ ; SCHÄFER Michael ⁽³⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Company Medical Service, Madaus AG, Cologne, ETATS-UNIS
⁽²⁾ CRM-Biometrics, Rheinbach, ALLEMAGNE
⁽³⁾ Product Development, Madaus AG, Cologne, ALLEMAGNE

Résumé / Abstract

Common colds are one of the most frequent acute illnesses with major economical impact. Echinaceae purpureae herba (Echinacin®, EC31J0) has shown promising results in the relief of common cold symptoms and the time taken to improvement compared to placebo. This study was aimed to confirm these findings by performing a randomised, double-blind, placebo-controlled clinical trial. A total of 80 adult male or female patients with first signs of a cold were recruited. The number of days of illness with a complete picture of the common cold (defined by the modified Jackson score of at least 5 points and experience of rhinorrhea and/or a subjective sensation of having a cold) was the primary endpoint. In the verum group the median time of illness was 6.0 days compared to 9.0 days in the placebo group, assigning zero time for patients without a complete picture (one-sided p = 0.0112). EC31J0 was well tolerated and clinically effective in alleviating symptoms more rapidly than placebo in patients with a common cold.

Revue / Journal Title

Arzneimittel-Forschung   ISSN 0004-4172   CODEN ARZNAD 

Source / Source

2001, vol. 51, n^o7, pp. 563-568 (33 ref.)

Langue / Language

Anglais

Editeur / Publisher

Cantor, Aulendorf, ALLEMAGNE  (1951) (Revue)

Mots-clés anglais / English Keywords

Plant origin ; Medicinal plant ; Pharmacognosy ; Common cold ; Phytotherapy ; Treatment ; Treatment efficiency ; Human ; Placebo ; Comparative study ; Randomization ; Controlled therapeutic trial ; Double blind study ; Viral disease ; Infection ; ENT disease ; Nose disease ;

Mots-clés français / French Keywords

Origine végétale ; Plante médicinale ; Pharmacognosie ; Rhume banal ; Phytothérapie ; Traitement ; Efficacité traitement ; Homme ; Placebo ; Etude comparative ; Randomisation ; Essai thérapeutique contrôlé ; Etude double insu ; Echinacea purpurea ; EC 31 JO ; Virose ; Infection ; ORL pathologie ; Nez pathologie ;

Mots-clés espagnols / Spanish Keywords

Origen vegetal ; Planta medicinal ; Farmacognosia ; Resfriado común ; Fitoterapia ; Tratamiento ; Eficacia tratamiento ; Hombre ; Placebo ; Estudio comparativo ; Aleatorización ; Ensayo terapéutico controlado ; Estudio doble ciego ; Virosis ; Infección ; ORL patología ; Nariz patología ;

Localisation / Location

INIST-CNRS, Cote INIST : 565, 35400009851826.0060