Titre du document / Document title

In vitro activity of sertaconazole, fluconazole, ketoconazole, fenticonazole, clotrimazole and itraconazole against pathogenic vaginal yeast isolates

Auteur(s) / Author(s)

PALACIN C. ⁽¹⁾ ; TARRAGO C. ⁽¹⁾ ; AGUT J. ⁽¹⁾ ; GUGLIETTA A. ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Department of Microbiology, Centro de Investigación Grupo Ferrer, Barcelona, ESPAGNE

Résumé / Abstract

The in vitro activity of sertaconazole was compared with those of the most commonly used vaginal antimycotic agents - fluconazole, ketoconazole, fenticonazole, clotrimazole and itraconazole - against 94 strains of clinical isolates of Candida spp. using a macrodilution method in Casitone agar medium. The sertaconazole concentration (μg/ml), at which 90% of the strains were inhibited, was 0.06 for C. albicans, 0.25 for C. glabrata and C. parapsilosis. 1 for C. krusei and 2 for C. tropicalis. These values show that sertaconazole is one of the most active products against yeasts causing vulvovaginal candidiasis, its activity against C. glabrata being particularly relevant.

Revue / Journal Title

Methods and findings in experimental and clinical pharmacology   ISSN 0379-0355 

Source / Source

2001, vol. 23, n^o2, pp. 61-64 (21 ref.)

Langue / Language

Anglais

Editeur / Publisher

Prous, Barcelona, ESPAGNE  (1979) (Revue)

Mots-clés anglais / English Keywords

Sertaconazole ; Fluconazole ; Ketoconazole ; Fenticonazole ; Clotrimazole ; Vaginitis ; Mycosis ; Itraconazole ; Antifungal agent ; Comparative study ; Candida ; Clinical isolate ; Human ; In vitro ; Female ; Triazole derivatives ; Imidazole derivatives ; Infection ; Fungi Imperfecti ; Fungi ; Thallophyta ; Female genital diseases ; Vaginal diseases ;

Mots-clés français / French Keywords

Sertaconazole ; Fluconazole ; Kétoconazole ; Fenticonazole ; Clotrimazole ; Vaginite ; Mycose ; Itraconazole ; Antifongique ; Etude comparative ; Candida ; Isolat clinique ; Homme ; In vitro ; Femelle ; Triazole dérivé ; Imidazole dérivé ; Infection ; Fungi Imperfecti ; Fungi ; Thallophyta ; Appareil génital femelle pathologie ; Vagin pathologie ;

Mots-clés espagnols / Spanish Keywords

Sertaconazol ; Fluconazol ; Ketoconazol ; Fenticonazol ; Clotrimazol ; Vaginitis ; Micosis ; Itraconazol ; Antifúngico ; Estudio comparativo ; Candida ; Aislado clinico ; Hombre ; In vitro ; Hembra ; Triazol derivado ; Imidazol derivado ; Infección ; Fungi Imperfecti ; Fungi ; Thallophyta ; Aparato genital hembra patología ; Vagina patología ;

Localisation / Location

INIST-CNRS, Cote INIST : 18217, 35400009556656.0020